SynthesisOncotarget2017
Lymphovascular invasion is a high risk factor for stage I/II colorectal cancer: a systematic review and meta-analysis.
Synthesis in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Perineural invasion is increased in patients receiving colonic stenting as a bridge to surgery: a systematic review and meta-analysis.Techniques in coloproctology · 2021Pooled it
- Prognostic value of lymphovascular invasion and CEA for cancer-specific survival in octogenarian colorectal cancer patients.World journal of surgical oncology · 2026Article
- Interpretable MRI Subregional Radiomics-Deep Learning Model for Preoperative Lymphovascular Invasion Prediction in Rectal Cancer: A Dual-Center Study.Journal of imaging informatics in medicine · 2026Article
- Primary tissue metabolic fingerprinting for efficient diagnosis of lymph node metastasis and metabolic reprogramming mechanisms in colorectal cancer.Materials today. Bio · 2026Article
- The role of the lymphatic network in colorectal cancer: anatomy, molecular drivers and management.Annals of gastroenterology · 2026Review
- The LVI Component Hypothesis: the lymphatic-to-vascular invasion ratio as an enrichment biomarker for therapy with PD-L1×VEGF-A bispecific antibodies.Frontiers in immunology · 2026Article
- Association of preoperative CT-derived visceral adipose tissue index with synchronous metastasis and metastasis-free survival after curative-intent surgery in colorectal cancer.Frontiers in oncology · 2026Article
- Integrative multi-region MRI radiomics and clinical nomogram for preoperative lymphovascular invasion prediction in rectal cancer: a multicenter validation.BMC medical imaging · 2025Article
- Prognostic Factors in Colorectal Liver Metastases: An Exhaustive Review of the Literature and Future Prospectives.Cancers · 2025Review
- Computational pathology applied to clinical colorectal cancer cohorts identifies immune and endothelial cell spatial patterns predictive of outcome.The Journal of pathology · 2025Article
- Lymphovascular invasion in colorectal cancers: can we predict it preoperatively?Annals of coloproctology · 2024Article
- Characteristics and outcomes of rectal cancer in patients with inflammatory bowel disease: a single-center experience.Updates in surgery · 2024Article
- Determinants of survival and recurrence in patients with stage I colorectal cancer.Frontiers in surgery · 2024Article
- Predictors of early colorectal cancer metastasis to lymph nodes: providing rationale for therapy decisions.Frontiers in oncology · 2024Review
- The Usefulness of Elastin Staining to Detect Vascular Invasion in Cancer.International journal of molecular sciences · 2023Review
- Is there no need to discuss adjuvant chemotherapy in stage II colon cancer patients with high tumor budding and lymphovascular invasion?Langenbeck's archives of surgery · 2023Article
- Evaluation of Adjuvant Chemotherapy Survival Outcomes Among Patients With Surgically Resected Pancreatic Carcinoma With Node-Negative Disease After Neoadjuvant Therapy.JAMA surgery · 2023Article
- KCNQ1 and lymphovascular invasion are key features in a prognostic classifier for stage II and III colon cancer.BMC cancer · 2022Article
- Current Perspectives on the Importance of Pathological Features in Prognostication and Guidance of Adjuvant Chemotherapy in Colon Cancer.Current oncology (Toronto, Ont.) · 2022Article
- Recurrence-Free Survival Outcomes Based on Novel Classification Combining Lymphovascular Invasion, Perineural Invasion, and T4 Status in Stage II-III Colon Cancer.Cancer management and research · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prognostic value of lymphovascular invasion (LVI) in stage I/II colorectal cancer (CRC) does not reach a consensus. To systematically assess prognostic significance of LVI, databases of PubMed, Web of Science, and Embase were searched from inception up to 10 Dec 2016. The pooled hazard ratio (HR) and 95% confidence intervals (CI) were used to determine the prognostic effects. Nineteen relevant studies including 9881 total patients were enrolled. Our results showed that LVI is significantly associated with poor prognosis in overall survival (OS) (HR=2.15, 95 % CI=1.72-2.68, P < 0.01) and disease-free survival (DFS) (HR=1.73, 95% CI=1.50-1.99, P < 0.01), which is similar in stage II patients. Further subgroup analysis revealed that the significance of the association between LVI and worse prognosis in CRC patients is not affected by below factors, including geographic setting, LVI positive rate, treatment, tumor site, and quality of the study. The current meta-analysis suggests that LVI may be a poor prognostic factor for stage I/II CRC patients.
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