ArticleEmerging infectious diseases2017
Genomic Characterization of Recrudescent Plasmodium malariae after Treatment with Artemether/Lumefantrine.
Article in Emerging infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Ten years of Plasmodium malariae infections in an International Health Reference Center in Barcelona: temporal trends and insights.Malaria journal · 2026Observational
- Unraveling the origins and features of long-latency Plasmodium malariae infections: a comprehensive epidemiological, clinical, and genetic study of seven cases in Guangdong Province (2014-2022).BMC infectious diseases · 2026Article
- Plasmodium malariae is an overlooked malaria parasite with emerging challenges.Communications medicine · 2026Review
- Congenital infection with Plasmodium malariae: a rare case of intrauterine transmission in Germany.Malaria journal · 2025Article
- Malian field isolates provide insight into Plasmodium malariae intra-erythrocytic development and invasion.PLoS neglected tropical diseases · 2025Article
- Imported malaria into Australia: surveillance insights and opportunities.Journal of travel medicine · 2024Article
- Plasmodium malariae structure and genetic diversity in sub-Saharan Africa determined from microsatellite variants and linked SNPs in orthologues of antimalarial resistance genes.Scientific reports · 2022Article
- The presence of Plasmodium malariae and Plasmodium knowlesi in near malaria elimination setting in western Indonesia.Malaria journal · 2022Article
- The primate malaria parasites Plasmodium malariae, Plasmodium brasilianum and Plasmodium ovale spp.: genomic insights into distribution, dispersal and host transitions.Malaria journal · 2022Review
- Population genomics in neglected malaria parasites.Frontiers in microbiology · 2022Review
- Article
- Development of Cooperative Primer-Based Real-Time PCR Assays for the Detection of Plasmodium malariae and Plasmodium ovale.The Journal of molecular diagnostics : JMD · 2021Article
- Article
- Seroprevalence and Parasite Rates ofThe American journal of tropical medicine and hygiene · 2020Article
- Selective whole genome amplification of Plasmodium malariae DNA from clinical samples reveals insights into population structure.Scientific reports · 2020Article
- Polymorphic markers for identification of parasite population in Plasmodium malariae.Malaria journal · 2020Article
- Genome-wide microsatellite characteristics of five human Plasmodium species, focusing on Plasmodium malariae and P. ovale curtisi.Parasite (Paris, France) · 2020Article
- 8-Aminoquinoline Therapy for Latent Malaria.Clinical microbiology reviews · 2019Review
- Characterization of Plasmodium infections among inhabitants of rural areas in Gabon.Scientific reports · 2019Article
- A case of Plasmodium malariae recurrence: recrudescence or reinfection?Malaria journal · 2019Review
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
Abstract
Plasmodium malariae is the only human malaria parasite species with a 72-hour intraerythrocytic cycle and the ability to persist in the host for life. We present a case of a P. malariae infection with clinical recrudescence after directly observed administration of artemether/lumefantrine. By using whole-genome sequencing, we show that the initial infection was polyclonal and the recrudescent isolate was a single clone present at low density in the initial infection. Haplotypic analysis of the clones in the initial infection revealed that they were all closely related and were presumably recombinant progeny originating from the same infective mosquito bite. We review possible explanations for the P. malariae treatment failure and conclude that a 3-day artemether/lumefantrine regimen is suboptimal for this species because of its long asexual life cycle.
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Registered trials
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