ArticleRNA biology2017
Issues in current microRNA target identification methods.
Article in RNA biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Targetome-defined miR-181c signaling from extracellular vesicles governs periodontal MSC fate via RNF150-MAP3K5.Cell communication and signaling : CCS · 2026Article
- Comprehensive and bias-aware analysis of small RNA NGS data for biomarker detection with caRNAge.Extracellular vesicles and circulating nucleic acids · 2026Article
- MicroRNA expression in peripheral blood of children with asthma and the role of miR-31-5p in childhood asthma progression.Scientific reports · 2025Article
- A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals.Nature reviews. Molecular cell biology · 2025Review
- Identification and characterization of host miRNAs that target the mouse mammary tumour virus (MMTV) genome.Open biology · 2024Article
- Regulatory features aid interpretation of 3'UTR variants.American journal of human genetics · 2024Article
- MicroRNA-mediated attenuation of branched-chain amino acid catabolism promotes ferroptosis in chronic kidney disease.Nature communications · 2023Article
- Identification of potential biomarkers for idiopathic pulmonary fibrosis and validation ofWorld journal of cardiology · 2023Article
- A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength.EMBO reports · 2023Article
- Article
- Recent findings on miR‑370 expression, regulation and functions in cancer (Review).Oncology reports · 2023Review
- miRNAs: The Road from Bench to Bedside.Genes · 2023Review
- Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of gene regulatory programs in cancers.Nucleic acids research · 2022Article
- Transgenic overexpression of microRNA-30d in pancreatic beta-cells progressively regulates beta-cell function and identity.Scientific reports · 2022Article
- Exosome-derived small non-coding RNAs reveal immune response upon grafting transplantation inOpen biology · 2022Article
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- Article
- microRNA-483 Protects Pancreatic β-Cells by Targeting ALDH1A3.Endocrinology · 2021Article
- Functions and Targets of miR-335 in Cancer.OncoTargets and therapy · 2021Review
- miRNA target identification and prediction as a function of time in gene expression data.RNA biology · 2020Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
microRNAs are currently believed to control a large diversity of physiologic processes, through the collective repression of thousands of target genes. Both experimental and computational analyses indeed suggest that each microRNA regulates tens or hundreds of genes. But some observations suggest that the phenotypic consequences of many published miRNA/mRNA interactions are dubious. For example, the reported amplitude of miRNA-guided repression is very small, while biologic processes tend to be robust to small changes in gene expression. We recently showed, on one particular miRNA, that for most predicted targets, miRNA-guided repression is even smaller than inter-individual variability among wild-type specimens. We also put forward several sources of computational false positives. These issues are generally neglected by the scientific community, probably resulting in the frequent publication of irreproducible or misinterpreted results regarding microRNA function. We propose novel types of analyses, easily accessible to the community, that could help improve microRNA target identification.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.