ArticleScientific reports2017
Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.Nature communications · 2019Pooled it
- The Family Check-up Intervention Moderates Polygenic Influences on Long-Term Alcohol Outcomes: Results from a Randomized Intervention Trial.Prevention science : the official journal of the Society for Prevention Research · 2019Trial
- Aberrant one-carbon metabolism and ancestral genetics underlie edematous severe acute malnutrition.Nature communications · 2026Article
- Chromosome 21 variants tied to severe asthma exacerbations: A genome-wide association study in a Brazilian population.The journal of allergy and clinical immunology. Global · 2025Article
- Heterogeneous genetic architectures of prostate cancer susceptibility in sub-Saharan Africa.Nature genetics · 2024Article
- Building a vertically integrated genomic learning health system: The biobank at the Colorado Center for Personalized Medicine.American journal of human genetics · 2024Article
- Implementation of a genotyped African population cohort, with virtual follow-up: A feasibility study in the Western Cape Province, South Africa.Wellcome open research · 2024Article
- Genome-wide association study of leprosy in Malawi and Mali.PLoS pathogens · 2022Article
- A functional genomics approach in Tanzanian population identifies distinct genetic regulators of cytokine production compared to European population.American journal of human genetics · 2022Article
- Polygenic prediction of atopic dermatitis improves with atopic training and filaggrin factors.The Journal of allergy and clinical immunology · 2022Article
- Characterizing the Genetic Architecture of Parkinson's Disease in Latinos.Annals of neurology · 2021Article
- Genetics and Epigenetics in Asthma.International journal of molecular sciences · 2021Review
- Human genetics and malaria resistance.Human genetics · 2020Review
- Clinical implementation of pharmacogenomics via a health system-wide research biobank: the University of Colorado experience.Pharmacogenomics · 2020Article
- Easy-HLA: a validated web application suite to reveal the full details of HLA typing.Bioinformatics (Oxford, England) · 2020Article
- Evaluating the promise of inclusion of African ancestry populations in genomics.NPJ genomic medicine · 2020Review
- Ancestry-specific polygenic scores and SNP heritability of 25(OH)D in African- and European-ancestry populations.Human genetics · 2019Article
- The Future of Genomic Studies Must Be Globally Representative: Perspectives from PAGE.Annual review of genomics and human genetics · 2019Review
- Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospects.BMC medical genomics · 2019Review
- Odyssey: a semi-automated pipeline for phasing, imputation, and analysis of genome-wide genetic data.BMC bioinformatics · 2019Article
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
A primary goal of The Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) is to develop an 'African Diaspora Power Chip' (ADPC), a genotyping array consisting of tagging SNPs, useful in comprehensively identifying African specific genetic variation. This array is designed based on the novel variation identified in 642 CAAPA samples of African ancestry with high coverage whole genome sequence data (~30× depth). This novel variation extends the pattern of variation catalogued in the 1000 Genomes and Exome Sequencing Projects to a spectrum of populations representing the wide range of West African genomic diversity. These individuals from CAAPA also comprise a large swath of the African Diaspora population and incorporate historical genetic diversity covering nearly the entire Atlantic coast of the Americas. Here we show the results of designing and producing such a microchip array. This novel array covers African specific variation far better than other commercially available arrays, and will enable better GWAS analyses for researchers with individuals of African descent in their study populations. A recent study cataloging variation in continental African populations suggests this type of African-specific genotyping array is both necessary and valuable for facilitating large-scale GWAS in populations of African ancestry.
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