ArticleScientific reports2017
Straight and rigid flagellar hook made by insertion of the FlgG specific sequence into FlgE.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Transposon mutant library reveals the complex regulatory network of biofilm formation inBiofilm · 2026Article
- Structure, Assembly, and Function of Flagella Responsible for Bacterial Locomotion.EcoSal Plus · 2023Review
- High-Resolution Rotation Assay of the Bacterial Flagellar Motor Near Zero Loads Using a Mutant Having a Rod-Like Straight Hook.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Structure of the molecular bushing of the bacterial flagellar motor.Nature communications · 2021Article
- Living in a Foster Home: The Single Subpolar Flagellum Fla1 ofBiomolecules · 2020Review
- Dynamic exchange of two types of stator units inComputational and structural biotechnology journal · 2020Review
- Structure of the native supercoiled flagellar hook as a universal joint.Nature communications · 2019Article
- Structure ofBiomolecules · 2019Article
- Flagella-Driven Motility of Bacteria.Biomolecules · 2019Review
- Architecture of the Bacterial Flagellar Distal Rod and Hook ofBiomolecules · 2019Article
- Bacterial flagellar axial structure and its construction.Biophysical reviews · 2018Review
- Insight into structural remodeling of the FlhA ring responsible for bacterial flagellar type III protein export.Science advances · 2018Article
- Evidence for the hook supercoiling mechanism of the bacterial flagellum.Biophysics and physicobiology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bacterial flagellar hook connects the helical flagellar filament to the rotary motor at its base. Bending flexibility of the hook allows the helical filaments to form a bundle behind the cell body to produce thrust for bacterial motility. The hook protein FlgE shows considerable sequence and structural similarities to the distal rod protein FlgG; however, the hook is supercoiled and flexible as a universal joint whereas the rod is straight and rigid as a drive shaft. A short FlgG specific sequence (GSS) has been postulated to confer the rigidity on the FlgG rod, and insertion of GSS at the position between Phe-42 and Ala-43 of FlgE actually made the hook straight. However, it remains unclear whether inserted GSS confers the rigidity as well. Here, we provide evidence that insertion of GSS makes the hook much more rigid. The GSS insertion inhibited flagellar bundle formation behind the cell body, thereby reducing motility. This indicates that the GSS insertion markedly reduced the bending flexibility of the hook. Therefore, we propose that the inserted GSS makes axial packing interactions of FlgE subunits much tighter in the hook to suppress axial compression and extension of the protofilaments required for bending flexibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.