Evidence map›Paper›PMID 28429746›Full record

ArticleScientific reports2017

The small G protein Arf6 expressed in keratinocytes by HGF stimulation is a regulator for skin wound healing.

Yuki Miura, Van Ngo Thai Bich, Momoko Furuya, Hiroshi Hasegawa, Satoru Takahashi, Naohiro Katagiri, Tsunaki Hongu, Yuji Funakoshi, Norihiko Ohbayashi, Yasunori Kanaho

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Deoxycholic acid aggravates necrotizing enterocolitis through downregulation of mesenchymal-epithelial transition factor expression.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
    Article
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  3. Review
  4. Article
  5. Article
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  7. Article
  8. HGF/c-MET Signaling in Melanocytes and Melanoma.International journal of molecular sciences · 2018
    Review
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  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yuki MiuraDepartment of Physiological Chemistry, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8578, Japan.
Van Ngo Thai BichDepartment of Physiological Chemistry, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8578, Japan.
Momoko FuruyaDepartment of Physiological Chemistry, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8578, Japan.
Hiroshi HasegawaDepartment of Physiological Chemistry, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8578, Japan.
Satoru TakahashiDepartment of Anatomy and Embryology, Faculty of Medicine and Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8578, Japan.
Naohiro KatagiriDepartment of Physiological Chemistry, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8578, Japan.
Tsunaki HonguDepartment of Physiological Chemistry, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8578, Japan.
Yuji FunakoshiDepartment of Physiological Chemistry, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8578, Japan.
Norihiko OhbayashiDepartment of Physiological Chemistry, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8578, Japan.
Yasunori KanahoDepartment of Physiological Chemistry, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8578, Japan.
University of Tsukuba · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The earlier step of cutaneous wound healing process, re-epithelialization of the wounded skin, is triggered by a variety of growth factors. However, molecular mechanisms through which growth factors trigger skin wound healing are less understood. Here, we demonstrate that hepatocyte growth factor (HGF)/c-Met signaling-induced expression of the small G protein Arf6 mRNA in keratinocytes is essential for the skin wound healing. Arf6 mRNA expression was dramatically induced in keratinocytes at the wounded skin, which was specifically suppressed by the c-Met inhibitor. Wound healing of the skin was significantly delayed in keratinocyte-specific Arf6 conditional knockout mice. Furthermore, Arf6 deletion from keratinocytes remarkably suppressed HGF-stimulated cell migration and peripheral membrane ruffle formation, but did not affect skin morphology and proliferation/differentiation of keratinocytes. These results are consistent with the notion that Arf6 expressed in skin keratinocytes through the HGF/c-Met signaling pathway in response to skin wounding plays an important role in skin wound healing by regulating membrane dynamics-based motogenic cellular function of keratinocytes.

Indexed as

Signal TransductionSkinWound HealingADP-Ribosylation Factor 6ADP-Ribosylation FactorsAnimalsHepatocyte Growth FactorKeratinocytesMiceMice, KnockoutReceptor Protein-Tyrosine KinasesADP-Ribosylation Factor 6ADP-Ribosylation FactorsARF6 protein, humanArf6 protein, mouseHepatocyte Growth FactorHGF protein, mouseReceptor Protein-Tyrosine KinasesRON protein

Identifiers

PMID28429746
PMCPMC5399375
OpenAlexW2607217722

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.