ArticleScientific reports2017
The evolutionary life cycle of the polysaccharide biosynthetic gene cluster based on the Sphingomonadaceae.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
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- Optimization of welan gum extraction and purification using lysozyme and alkaline protease.Applied microbiology and biotechnology · 2024Article
- Unique gel-like colony forming bacteriumHeliyon · 2024Article
- An exopolysaccharide pathway from a freshwaterJournal of bacteriology · 2024Article
- The production of ultrahigh molecular weight xanthan gum from a Sphingomonas chassis capable of co-utilising glucose and xylose from corn straw.Microbial biotechnology · 2024Article
- A novel exopolysaccharide pathway from a freshwaterbioRxiv : the preprint server for biology · 2023Article
- Genomic and physiological characterization of Novosphingobium terrae sp. nov., an alphaproteobacterium isolated from Cerrado soil containing a mega-sized chromid.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Characterizing microbial communities associated with northern root-knot nematode (Frontiers in microbiology · 2023Article
- Article
- Total nitrogen influence bacterial community structure of active layer permafrost across summer and winter seasons in Ny-Ålesund, Svalbard.World journal of microbiology & biotechnology · 2022Article
- Complete Genome Sequence of Sphingobium xenophagum PH3-15, Isolated from La Roche-Posay Thermal Water Sources.Microbiology resource announcements · 2021Article
- Batch-Learning Self-Organizing Map Identifies Horizontal Gene Transfer Candidates and Their Origins in Entire Genomes.Frontiers in microbiology · 2020Article
- Genomewide characterisation of the genetic diversity of carotenogenesis in bacteria of the order Sphingomonadales.Microbial genomics · 2018Article
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10 authors.
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Abstract
Although clustering of genes from the same metabolic pathway is a widespread phenomenon, the evolution of the polysaccharide biosynthetic gene cluster remains poorly understood. To determine the evolution of this pathway, we identified a scattered production pathway of the polysaccharide sanxan by Sphingomonas sanxanigenens NX02, and compared the distribution of genes between sphingan-producing and other Sphingomonadaceae strains. This allowed us to determine how the scattered sanxan pathway developed, and how the polysaccharide gene cluster evolved. Our findings suggested that the evolution of microbial polysaccharide biosynthesis gene clusters is a lengthy cyclic process comprising cluster 1 → scatter → cluster 2. The sanxan biosynthetic pathway proved the existence of a dispersive process. We also report the complete genome sequence of NX02, in which we identified many unstable genetic elements and powerful secretion systems. Furthermore, nine enzymes for the formation of activated precursors, four glycosyltransferases, four acyltransferases, and four polymerization and export proteins were identified. These genes were scattered in the NX02 genome, and the positive regulator SpnA of sphingans synthesis could not regulate sanxan production. Finally, we concluded that the evolution of the sanxan pathway was independent. NX02 evolved naturally as a polysaccharide producing strain over a long-time evolution involving gene acquisitions and adaptive mutations.
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