ArticleNature communications2017
A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Identification and targeting of regulators of SARS-CoV-2-host interactions in the airway epithelium.Science advances · 2025Article
- Human prostate organoid generation and the identification of prostate development drivers using inductive rodent tissues.Development (Cambridge, England) · 2023Article
- Prostate organogenesis.Development (Cambridge, England) · 2022Article
- ETS-related gene (ERG) undermines genome stability in mouse prostate progenitors via Gsk3β dependent Nkx3.1 degradation.Cancer letters · 2022Article
- Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022Article
- Detection of Prognostic Biomarkers for Hepatocellular Carcinoma through CircRNA-associated CeRNA Analysis.Journal of clinical and translational hepatology · 2022Article
- Chromatin and Epigenetic Dysregulation of Prostate Cancer Development, Progression, and Therapeutic Response.Cancers · 2021Review
- Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages.Cell · 2021Article
- An expanded universe of cancer targets.Cell · 2021Review
- Mechanism-Centric Approaches for Biomarker Detection and Precision Therapeutics in Cancer.Frontiers in genetics · 2021Review
- The Master Regulator Protein BAZ2B Can Reprogram Human Hematopoietic Lineage-Committed Progenitors into a Multipotent State.Cell reports · 2020Article
- CXCL12γ induces human prostate and mammary gland development.The Prostate · 2020Article
- Pluripotent stem cell differentiation as an emerging model to study human prostate development.Stem cell research & therapy · 2020Review
- Propagation of human prostate tissue from induced pluripotent stem cells.Stem cells translational medicine · 2020Article
- SOX2 has dual functions as a regulator in the progression of neuroendocrine prostate cancer.Laboratory investigation; a journal of technical methods and pathology · 2020Article
- Elucidating synergistic dependencies in lung adenocarcinoma by proteome-wide signaling-network analysis.PloS one · 2019Article
- Identification of a putative competitive endogenous RNA network for lung adenocarcinoma using TCGA datasets.PeerJ · 2019Article
- Cooperation of loss ofDisease models & mechanisms · 2018Article
- Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm.Nature communications · 2018Article
- Lineage Plasticity in Cancer Progression and Treatment.Annual review of cancer biology · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
To date, reprogramming strategies for generating cell types of interest have been facilitated by detailed understanding of relevant developmental regulatory factors. However, identification of such regulatory drivers often represents a major challenge, as specific gene combinations may be required for reprogramming. Here we show that a computational systems approach can identify cell type specification genes (master regulators) that act synergistically, and demonstrate its application for reprogramming of fibroblasts to prostate tissue. We use three such master regulators (FOXA1, NKX3.1 and androgen receptor, AR) in a primed conversion strategy starting from mouse fibroblasts, resulting in prostate tissue grafts with appropriate histological and molecular properties that respond to androgen-deprivation. Moreover, generation of reprogrammed prostate does not require traversal of a pluripotent state. Thus, we describe a general strategy by which cell types and tissues can be generated even with limited knowledge of the developmental pathways required for their specification in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.