Trial reportJournal of cutaneous pathology2017
Inflammatory features of frontal fibrosing alopecia.
Trial report in Journal of cutaneous pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- The Polygenic Architecture of Human Diseases Affecting the Hair Follicle.The Journal of investigative dermatology · 2026Review
- Hair follicle immune privilege in autoimmune and immune-mediated alopecias: paths toward reestablishing immune tolerance.Frontiers in medicine · 2026Review
- Proteomic Profiling of Central Centrifugal Cicatricial Alopecia Reveals Role of Humoral Immune Response Pathway and Metabolic Dysregulation.JID innovations : skin science from molecules to population health · 2024Article
- Clinicopathological Features of Frontal Fibrosing Alopecia (FFA) in 26 females: A Retrospective Study.Iranian journal of pathology · 2024Article
- Frontal Fibrosing Alopecia: A Histopathological Comparison of the Frontal Hairline with Normal-Appearing Scalp.Journal of clinical medicine · 2022Article
- Frontiers in Lichen Planopilaris and Frontal Fibrosing Alopecia Research: Pathobiology Progress and Translational Horizons.JID innovations : skin science from molecules to population health · 2022Review
- Association between frontal fibrosing Alopecia and Rosacea: Results from clinical observational studies and gene expression profiles.Frontiers in immunology · 2022Article
- Frontal Fibrosing Alopecia: A Review.Journal of clinical medicine · 2021Review
- Frontal fibrosing alopecia: a disease that remains enigmatic.Postepy dermatologii i alergologii · 2020Review
- Characterization of the inflammatory features of central centrifugal cicatricial alopecia.Journal of cutaneous pathology · 2020Article
- Frontal fibrosing alopecia: An update on the hypothesis of pathogenesis and treatment.International journal of women's dermatology · 2019Review
- Frontal Fibrosing Alopecia: A Comprehensive Review with Recent Updates.Indian journal of dermatologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
introductionFrontal fibrosing alopecia (FFA) is a cicatricial alopecia typically occurring in postmenopausal women. The etiology and pathophysiology of FFA is poorly understood but thought to be immune mediated. This study aims to further explore the extent of fibrosis and the inflammatory microenvironment by characterizing Langerhans cells (LCs), helper T cells, cytotoxic T cells and B cells near hair follicles in FFA.
methodsEleven paraffin-embedded tissues from patients with a clinical and histopathologic diagnosis of FFA were selected for immunohistochemical studies using CD3, CD4, CD8, CD1a and CD20. The lymphocytes and LCs were counted around involved follicles. The CD4/CD8 T-lymphocyte ratios were calculated and compared to the CD4/CD8 T-lymphocyte ratios in uninvolved areas.
resultsOn histopathologic review, at least 35% of follicles in each case were affected by the disease with concentric perifollicular fibrosis and a perifollicular lichenoid lymphocytic infiltrate around the infundibuloisthmic portion of the hair follicle. There was an increase of perifollicular LCs (mean of 18, SD of 5.5) and intrafollicular LCs (mean of 14, SD of 4.3) in involved follicles compared to uninvolved follicles (P < .0001). The involved follicles also showed a relative decrease in the CD4/CD8 ratio indicating increased numbers of CD8+ T cells; a finding distinct from the CD4-predominant population in uninvolved follicles (P < .0001).
conclusionThe inflammatory features of FFA show a CD8-biased T-cell infiltrate with increased numbers of LCs in the infundibuloisthmic region. The increased LCs may represent an aberrant immune reaction promoting a CD8+ T-cell response.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.