Evidence map›Paper›PMID 28429303›Full record

ReviewCurrent allergy and asthma reports2017

Natural Evolution of IgE Responses to Mite Allergens and Relationship to Progression of Allergic Disease: a Review.

Daniela Posa, Stephanie Hofmaier, Stefania Arasi, Paolo Maria Matricardi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current allergy and asthma reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. EAACI Allergen Immunotherapy User's Guide.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020
    Review
  10. Sampling Devices for Indoor Allergen Exposure: Pros and Cons.Current allergy and asthma reports · 2019
    Review
  11. Review
  12. IgE, IgG1, and IgG4 Reactivity toBioMed research international · 2019
    Article
  13. Bedroom Allergen Exposure Beyond House Dust Mites.Current allergy and asthma reports · 2018
    Review
  14. Article
  15. Metazoan Parasite Vaccines: Present Status and Future Prospects.Frontiers in cellular and infection microbiology · 2018
    Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Daniela PosaDepartment of Paediatric Pneumology & Immunology, Charité - Universitätsmedizin Berlin, Augustenburger Platz, 1, 13353, Berlin, Germany.
Stephanie HofmaierDepartment of Paediatric Pneumology & Immunology, Charité - Universitätsmedizin Berlin, Augustenburger Platz, 1, 13353, Berlin, Germany.
Stefania ArasiDepartment of Paediatric Pneumology & Immunology, Charité - Universitätsmedizin Berlin, Augustenburger Platz, 1, 13353, Berlin, Germany.
Paolo Maria MatricardiDepartment of Paediatric Pneumology & Immunology, Charité - Universitätsmedizin Berlin, Augustenburger Platz, 1, 13353, Berlin, Germany. paolo.matricardi@charite.de.
Charité - Universitätsmedizin Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewAllergenic molecules of the house dust mite (HDM) are crucially important indoor allergens, contributing to allergic rhinitis and asthma around the globe. In the past years, recombinant molecules for diagnostics opened new pathways to investigate individual sensitization profiles and new chances for the prevention and treatment of HDM allergy. This review summarizes the latest findings on the evolution of IgE responses towards mite allergens. RECENT

findingsSeveral cross-sectional and longitudinal studies confirmed the role of Der p 1 and Der p 2 as major allergenic proteins of the HDM. A newly identified player is the major allergen Der p 23. Apart from identifying the early sensitization towards this molecule as a risk factor for asthma in school age, a recent longitudinal study described sensitization patterns showing that the production of IgE usually starts towards a group of initiator proteins and may stay monomolecular or expand to an oligo- or even polymolecular stage. This phenomenon also correlates to clinical symptoms. A relation between a broad sensitization pattern and symptom severity has also been shown cross-sectionally. Individual sensitization profiles towards HDM allergens provide important information to evaluate a patient's current stage and risk for clinical symptoms. This knowledge paves the way for an early and adequate prevention and/or treatment.

Indexed as

AllergensAnimalsCross-Sectional StudiesDisease ProgressionHumansImmunoglobulin EImmunotherapyPyroglyphidaeRisk FactorsAllergensImmunoglobulin EAllergic rhinitisAsthmaHouse dust miteIgE responseMolecular allergologySpecific immunotherapy

Identifiers

PMID28429303
OpenAlexW2606313013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.