ArticlePathology oncology research : POR2018
Primary Ewing Sarcoma / Primitive Neuroectodermal Tumor of the Kidney: A Clinicopathologic Study of 23 Cases.
Article in Pathology oncology research : POR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Primary Ewing sarcoma of the kidney mimicking hydatid cyst: A case report with literature review.Radiology case reports · 2026Article
- Renal ewing sarcoma in a young female: a case report and review of targeted therapy.Frontiers in surgery · 2025Article
- Renal Ewing sarcoma with inferior vena cava (IVC) tumor thrombosis; A case report.Radiology case reports · 2024Article
- Primary Ewing sarcoma of the kidney mimicking cystic papillary renal cell carcinoma in an older patient: A case report.World journal of clinical cases · 2024Article
- Article
- Pediatric Ewing Sarcoma of Kidney: A Case Series and Review of Literature.Journal of cancer & allied specialties · 2024Article
- Clinicodemographic characteristics of extraosseous ewing sarcoma: A comparative meta-analysis of pediatric and adult patients.Journal of orthopaedics · 2023Review
- Safety profile of vascular endothelial growth factor receptor tyrosine-kinase inhibitors in pediatrics: a pharmacovigilance disproportionality analysis.Frontiers in pharmacology · 2023Article
- Extraosseous Ewing Sarcoma in Children: A Systematic Review and Meta-Analysis of Clinicodemographic Characteristics.Children (Basel, Switzerland) · 2022Review
- A rare radiotherapy-sensitive primitive neuroectodermal tumor withThe Journal of international medical research · 2022Review
- Primary Adult Renal Ewing's Sarcoma: A Rare Entity.Cureus · 2022Article
- A case report of melanotic neuroectodermal tumor of infancy complicated with congenital heart disease and hypothyroidism.Frontiers in cardiovascular medicine · 2022Article
- Ewing sarcoma of the jejunum: A case report and literature review.World journal of gastrointestinal surgery · 2021Article
- Management of primary Ewing sarcoma of the kidney with inferior vena cava (IVC) tumor thrombosis.Urology case reports · 2021Article
- Primary Renal Ewing Sarcoma in Children and Young Adults.Journal of pediatric hematology/oncology · 2020Article
- Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Kidney: The MD Anderson Cancer Center Experience.Cancers · 2020Article
- Outcome of multidisciplinary treatment of peripheral primitive neuroectodermal tumor.Scientific reports · 2020Article
- Giant primitive neuroectodermal pelvic tumour: a case report and literature review.The Journal of international medical research · 2020Review
- Review
- Qualitative and quantitative CECT features for differentiating renal primitive neuroectodermal tumor from the renal cell carcinoma and its subtypes.The British journal of radiology · 2019Article
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Authors and funding
5 authors.
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Abstract
Primary Ewing sarcoma / primitive neuroectodermal tumor (ES) of the kidney is a rare neoplasm with limited clinicopathologic data. We report 23 such cases with no history of ES elsewhere in the body. The patients included 13 male and 10 female, aged 8-70 years (mean, 31 years). The average tumor size was 11.7 cm (range, 5-20 cm). Microscopic analysis showed predominantly lobular growth (n = 14), with focal papillary (n = 3), alveolar (n = 1), and hemangiopericytoma-like (n = 1) patterns. Several tumors (n = 11) exhibited robust mitotic activity (>10 mitoses/10 high-power fields). Necrosis (n = 13) and lymphovascular invasion (n = 14) were common. Homer Wright rosettes (n = 6) and perivascular pseudorosettes (n = 1) were also identified. The tumors invaded the renal sinus or perinephric fat (n = 11), renal vein (n = 13), and adrenal gland (n = 2). Molecular and fluorescence in situ hybridization analysis showed rearrangement of EWSR1 gene (10/10), associated with EWSR1-FLI1 gene fusion (7/10). All patients with follow-up information (n = 18) had metastasis, commonly in the lungs (n = 12) and bone (n = 6). Twelve patients died of disease in a mean of 21 months; 6 patients were alive at a mean of 49 months after diagnosis. Primary kidney ES usually present at an advanced stage with extrarenal spread and metastasis. Although renal ES share histologic, immunohistochemical, and molecular features with their bone and soft tissue counterparts, they appear to be more aggressive tumors with poorer clinical outcome.
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