Evidence map›Paper›PMID 28429264›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2017

Lymphocytes incubated in the presence of IL-2 lose the capacity for chemotaxis but acquire antitumor activity.

E A Romanova, E A Dukhanina, T N Sharapova, L P Sashchenko, N V Gnuchev, D V Yashin

Abstract read
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In one paragraph

Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

E A RomanovaInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
E A DukhaninaInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
T N SharapovaInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
L P SashchenkoInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
N V GnuchevInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
D V YashinInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia. yashin_co@mail.ru.
Institute of Gene Biology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Naïve non-activated lymphocytes are capable of releasing the chemoattractant complex Tag7-Mts1 and can migrate along the gradient of its concentration. After activation of these cells by IL-2, they acquire the abilities to kill tumor cells and to release the cytotoxic Tag7-Hsp70 complex, which is accompanied by a loss of both the Tag7-Mts1-mediated lymphocyte chemotaxis and the ability to release this chemoattractant into the conditioned medium.

Indexed as

Immunity, CellularChemotaxisCyclin-Dependent Kinase Inhibitor p16CytokinesHumansInterleukin-2K562 CellsLymphocyte ActivationLymphocytesNeoplasmsCyclin-Dependent Kinase Inhibitor p16CytokinesIL2 protein, humanInterleukin-2PGLYRP1 protein, human

Identifiers

PMID28429264
OpenAlexW2607001670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.