Evidence map›Paper›PMID 28429237›Full record

ArticleJournal of neuro-oncology2017

Atypical and anaplastic meningioma: outcomes in a population based study.

T Garzon-Muvdi, W Yang, M Lim, H Brem, J Huang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Role of adjuvant radiotherapy in atypical (WHO grade II) and anaplastic (WHO grade III) meningiomas: a systematic review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021
    Pooled it
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  10. Meningioma recurrence: Time for an online prediction tool?Surgical neurology international · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

T Garzon-MuvdiDepartment of Neurosurgery, Johns Hopkins Hospital, 1800 Orleans Street, Zayed 6115F, Baltimore, MD, 21287, USA.ORCID http://orcid.org/0000-0002-2198-9757
W YangDepartment of Neurosurgery, Johns Hopkins Hospital, 1800 Orleans Street, Zayed 6115F, Baltimore, MD, 21287, USA.
M LimDepartment of Neurosurgery, Johns Hopkins Hospital, 1800 Orleans Street, Zayed 6115F, Baltimore, MD, 21287, USA.
H BremDepartment of Neurosurgery, Johns Hopkins Hospital, 1800 Orleans Street, Zayed 6115F, Baltimore, MD, 21287, USA.
J HuangDepartment of Neurosurgery, Johns Hopkins Hospital, 1800 Orleans Street, Zayed 6115F, Baltimore, MD, 21287, USA. jhuang24@jhmi.edu.ORCID http://orcid.org/0000-0002-0675-1935
Johns Hopkins Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atypical and anaplastic meningiomas (AAM) are aggressive tumors. This study is aimed at examining associations between patient and tumor-related factors and tumor-related death in patients with AAM. We conducted a population-based cohort study utilizing prospectively collected data from the Surveillance, Epidemiology, and End Results (SEER) database. Patients with diagnosis of AAM from 1973 to 2012 in the SEER database were included. Patients lacking clinical information were excluded. Multivariate analysis between patient and lesion characteristics, and AAM-related death was performed to adjust for confounding factors. We identified and included 522 patients in our study. Mean age at diagnosis was 60.8 ± 15.7 years. The majority of patients were White(73%), 15.5% Black, and 9.8% Asian. Average tumor size was 48.2 ± 20.3 mm. The tumor was locally confined in 57.1%, whereas it had intracranial extension in 29.3%, and extracranial extension in 8.8% of patients. The vast majority (94.8%) of tumors were supratentorial. Gross total resection (GTR) was documented in 65.5% of patients. Age at diagnosis (p = 0.001), tumor size (p = 0.003), surgery result (GTR vs. subtotal resection, p = 0.027), and radiation therapy (p = 0.2) were found to be significantly different between the comparison groups. In a multivariate proportional competing risk regression analysis age (HR 1.03, CI [1.01,1.04], p < 0.001), infratentorial location (HR 2.81, CI [1.20, 6.56], p = 0.017), tumor size (HR 1.01, CI [1.00,1.02], p = 0.032),and radiation treatment (HR 1.52, CI [1.11, 2.09], p = 0.01) were significantly associated with tumor-related death. The association of age at diagnosis, tumor size, location, and radiotherapy with overall survival in patients with AAM is demonstrated. The results provide a context for individualized treatment plans in patients with AAM. Additional studies focusing on issues such as the use of radiation and chemotherapy will clarify the best modality to achieve disease control.

Indexed as

Treatment OutcomeAdultAgedAged, 80 and overAge FactorsAnalysis of VarianceCohort StudiesCommunity Health PlanningFemaleHumansKaplan-Meier EstimateMaleMeningeal NeoplasmsMeningiomaMiddle AgedNational Cancer Institute (U.S.)Atypical meningiomaExtent of resectionRadiation

Identifiers

PMID28429237
OpenAlexW2607058987

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.