Evidence map›Paper›PMID 28429084›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2017

Rs4878104 contributes to Alzheimer's disease risk and regulates DAPK1 gene expression.

Yang Hu, Liang Cheng, Ying Zhang, Weiyang Bai, Wenyang Zhou, Tao Wang, Zhifa Han, Jian Zong, Shuilin Jin, Jun Zhang and 2 more

Abstract read
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
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  5. Article
  6. The Genetics of Alzheimer's Disease in the Chinese Population.International journal of molecular sciences · 2020
    Review
  7. Article
  8. Review
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yang HuSchool of Life Science and Technology, Harbin Institute of Technology, Room 307, Building 2E, Science Park, Yikuang Street, Nangang District, Harbin, 150080, China.
Liang ChengSchool of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.
Ying ZhangDepartment of Pharmacy, Heilongjiang Province Land Reclamation Headquarters General Hospital, Harbin, China.
Weiyang BaiSchool of Life Science and Technology, Harbin Institute of Technology, Room 307, Building 2E, Science Park, Yikuang Street, Nangang District, Harbin, 150080, China.
Wenyang ZhouSchool of Life Science and Technology, Harbin Institute of Technology, Room 307, Building 2E, Science Park, Yikuang Street, Nangang District, Harbin, 150080, China.
Tao WangSchool of Life Science and Technology, Harbin Institute of Technology, Room 307, Building 2E, Science Park, Yikuang Street, Nangang District, Harbin, 150080, China.
Zhifa HanSchool of Life Science and Technology, Harbin Institute of Technology, Room 307, Building 2E, Science Park, Yikuang Street, Nangang District, Harbin, 150080, China.
Jian ZongSchool of Life Science and Technology, Harbin Institute of Technology, Room 307, Building 2E, Science Park, Yikuang Street, Nangang District, Harbin, 150080, China.
Shuilin JinDepartment of Mathematics, Harbin Institute of Technology, Harbin, China.
Jun ZhangDepartment of Pharmacy, Heilongjiang Province Land Reclamation Headquarters General Hospital, Harbin, China.
Qinghua JiangSchool of Life Science and Technology, Harbin Institute of Technology, Room 307, Building 2E, Science Park, Yikuang Street, Nangang District, Harbin, 150080, China.
Guiyou LiuSchool of Life Science and Technology, Harbin Institute of Technology, Room 307, Building 2E, Science Park, Yikuang Street, Nangang District, Harbin, 150080, China. liuguiyou1981@163.com.ORCID http://orcid.org/0000-0002-1126-2888

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In 2006, a candidate gene study reported death-associated protein kinase 1 (DAPK1) rs4878104 variant to be significantly associated with Alzheimer's disease (AD) risk. However, the following studies showed inconsistent association results. Here, we conducted an updated analysis to investigate the potential association between rs4878104 and AD using a total of 60,751 samples (20,161 AD cases and 40,590 controls). In the pooled population, the results based on the allele and genotype genetic models show that rs4878104 variant is not significantly associated with AD risk. Interestingly, we identified rs4878104 variant to be significantly associated with AD risk in American population and Chinese population in subgroup analysis. Using multiple large-scale expression quantitative trait loci datasets, we further found that rs4878104 T allele could significantly regulate increased DAPK1 expression in European population. These findings suggest that rs4878104 may contribute AD susceptibility by modifying DAPK1 expression in European population.

Indexed as

AllelesAlzheimer DiseaseApoptosis Regulatory ProteinsAsian PeopleDeath-Associated Protein KinasesFemaleGenetic Predisposition to DiseaseHumansMalePolymorphism, Single NucleotideRiskWhite PeopleApoptosis Regulatory ProteinsDAPK1 protein, humanDeath-Associated Protein KinasesAlzheimer’s diseaseDAPK1Expression quantitative trait lociGene expressionrs4878104

Identifiers

PMID28429084

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.