Evidence map›Paper›PMID 28428963›Full record

ArticleBioMed research international2017

Quercetin Inhibits Pulmonary Arterial Endothelial Cell Transdifferentiation Possibly by Akt and Erk1/2 Pathways.

Shian Huang, Xiulong Zhu, Wenjun Huang, Yuan He, Lingpin Pang, Xiaozhong Lan, Xiaorong Shui, Yanfang Chen, Can Chen, Wei Lei

Abstract read
In one paragraph

Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Bioactive compound combinations fromFrontiers in pharmacology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. The Role of Regulatory T Cells in Pulmonary Arterial Hypertension.Journal of the American Heart Association · 2019
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shian HuangCardiovascular Medicine Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
Xiulong ZhuDepartment of Cardiovascular Medicine, The People's Hospital of Gaozhou, Maoming 525200, China.
Wenjun HuangOutpatient Operating Room, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
Yuan HeDepartment of Cardiovascular Medicine, The People's Hospital of Gaozhou, Maoming 525200, China.
Lingpin PangCardiovascular Medicine Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
Xiaozhong LanTibetan Collaborative Innovation Center of Agricultural and Animal Husbandry Resources, Tibet Agricultural and Animal Husbandry College, Nyingchi 860000, China.
Xiaorong ShuiLaboratory of Cardiovascular Diseases, Guangdong Medical University, Zhanjiang 524001, China.
Yanfang ChenGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.ORCID 0000-0003-4153-4669
Can ChenCardiovascular Medicine Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.ORCID 0000-0001-9205-0221
Wei LeiCardiovascular Medicine Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.ORCID 0000-0002-4033-4799

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the effects and mechanisms of quercetin on pulmonary arterial endothelial cell (PAEC) transdifferentiation into smooth muscle-like cells. TGF-

Indexed as

ActinsCell ProliferationCell TransdifferentiationEndothelial CellsFactor VIIIGene Expression Regulation, DevelopmentalHumansHypertension, PulmonaryMAP Kinase Signaling SystemMyocytes, Smooth MuscleProto-Oncogene Proteins c-aktPulmonary ArteryQuercetinSignal TransductionTransforming Growth Factor beta1ACTA2 protein, humanActinsF8 protein, humanFactor VIIIProto-Oncogene Proteins c-aktQuercetinTransforming Growth Factor beta1

Identifiers

PMID28428963
PMCPMC5385898

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.