ArticleClinical and experimental reproductive medicine2017
Cardiovascular risk may be increased in women with unexplained infertility.
Article in Clinical and experimental reproductive medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Preventing cardiovascular disease after hypertensive disorders of pregnancy: Searching for the how and when.European journal of preventive cardiology · 2017Pooled it
- The Association of Female and Male Preconception Dyslipidemia With Live Birth in Couples Seeking Fertility Treatment.The Journal of clinical endocrinology and metabolism · 2024Trial
- Association of endometriosis with hematuria markers: A Mendelian randomization study.Medicine · 2026Article
- Chronic inflammatory activity in women with normogonadotropic anovulation complicated by subclinical thyroid dysfunction: a prospective cohort study.Frontiers in endocrinology · 2026Article
- Threshold effects of atherogenic index of plasma on female infertility risk: evidence from NHANES 2013-2018.BMC women's health · 2025Article
- Life's crucial 9 is inversely and linearly associated with female infertility prevalence: a cross-sectional analysis from NHANES 2013-2018.Scientific reports · 2025Article
- Longitudinal Measures of Cardiovascular Risk Factors Are Associated with Subfertility in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.medRxiv : the preprint server for health sciences · 2025Article
- Association between remnant cholesterol (RC) and endometriosis: a cross-sectional study based on NHANES data.Lipids in health and disease · 2025Article
- Self-reported infertility and longitudinal measures of cardiovascular risk factors: The CARDIA study.PloS one · 2025Article
- Association between depression and infertility risk among American women aged 18-45 years: the mediating effect of the NHHR.Lipids in health and disease · 2024Article
- Vascular Health of Females with History of Assisted Reproductive Technology.Journal of cardiovascular development and disease · 2024Article
- Review
- History of Infertility and Midlife Cardiovascular Health in Female Individuals.JAMA network open · 2024Article
- Associations between cardiovascular health and female infertility: A national population-based study.PloS one · 2024Article
- The relationship between cardiometabolic index and infertility in American adults: a population-based study.Frontiers in endocrinology · 2024Article
- Cuban Policosanol (RaydelMolecules (Basel, Switzerland) · 2023Article
- Balancing risks and rewards in the context of shared motherhood IVF.Human reproduction (Oxford, England) · 2023Article
- Infertility and Risk of Cardiovascular Disease: A Prospective Cohort Study.Journal of the American Heart Association · 2023Article
- Evaluation of Dysfunctional HDL by Myeloperoxidase/Paraoxonase Ratio in Unexplained Infertility Patients Undergoing IVF/ICSI.Journal of clinical medicine · 2023Article
- Subjects Conceived through Assisted Reproductive Technologies Display Normal Arterial Stiffness.Diagnostics (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveGrowing evidence suggests that increased cardiovascular disease (CVD) risk is associated with female infertility caused by conditions such as polycystic ovarian disease, obesity, thyroid dysfunction, and endometriosis. The aim of this study was to evaluate whether any relationship exists between CVD and unexplained infertility.
methodsSixty-five women with unexplained infertility and 65 fertile controls were enrolled in the study. CVD risk markers such as low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), triglycerides (TG), insulin resistance (defined by the homeostasis model assessment ratio), and high-sensitivity C-reactive protein (hs-CRP) were assessed.
resultsTG, TC, LDL, and hs-CRP levels were higher and HDL levels were lower in patients with unexplained infertility than in fertile controls (
conclusionOur study showed that women with unexplained infertility had an atherogenic lipid profile and elevated hs-CRP levels, suggesting a higher risk of developing CVD in the future. Further studies with larger groups are needed to investigate the nature of this link.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.