Evidence map›Paper›PMID 28428893›Full record

ArticleInternational journal of retina and vitreous2017

Characteristics and racial variations of polypoidal choroidal vasculopathy in tertiary centers in the United States and United Kingdom.

Tarek Alasil, Nelida Munoz, Pearse A Keane, Adnan Tufail, Patrick A Coady, Eduardo Novais, Talisa E de Carlo, Caroline R Baumal, Nadia K Waheed, Jay S Duker and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of retina and vitreous, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Tarek AlasilDepartment of Ophthalmology and Visual Sciences, School of Medicine, Yale University, New Haven, CT USA.
Nelida MunozMoorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK.
Pearse A KeaneMoorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK.
Adnan TufailMoorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK.
Patrick A CoadyDepartment of Ophthalmology and Visual Sciences, School of Medicine, Yale University, New Haven, CT USA.
Eduardo NovaisNew England Eye Center, Tufts Medical Center, Boston, MA USA.
Talisa E de CarloNew England Eye Center, Tufts Medical Center, Boston, MA USA.
Caroline R BaumalNew England Eye Center, Tufts Medical Center, Boston, MA USA.
Nadia K WaheedNew England Eye Center, Tufts Medical Center, Boston, MA USA.
Jay S DukerNew England Eye Center, Tufts Medical Center, Boston, MA USA.
Ron A AdelmanDepartment of Ophthalmology and Visual Sciences, School of Medicine, Yale University, New Haven, CT USA.
Tufts Medical Center · USYale University · USMoorfields Eye Hospital NHS Foundation Trust · GBUniversity College London · GB

Funding

Department of Health CS-2014-14-023
6 · The paper itself

Abstract

purposeTo evaluate the characteristics and racial variations amongst patients with polypoidal choroidal vasculopathy (PCV) in the United States and the United Kingdom.

methodsFundus photos and indocyanine green angiography images were evaluated in a multicenter retrospective study to establish the diagnosis of PCV. Visual acuity (VA) was recorded in ETDRS letter count.

resultsEighty eyes of 71 PCV patients (average age of 69.4 ± 10.4 years) were included in the analysis. Of the total 71 subjects, 46 (65%) were women, 33 (46.5%) were Blacks, 16 (22.5%) were Whites, 19 (26.8%) were Asians and 3 (4.2%) belonged to other races. The Black subgroup had vision gain of 3.5 letters. The White and Asian subgroups had vision loss of 13.1 and 3.5 letters, respectively. There was female predominance in Blacks (67%), Whites (69%), and Asians (58%). PCV was found to be a bilateral disease in 14 patients (20%). There was significant decrease of 7 letters with every decade increase in age (p = 0.005). Final VA was worse in males when compared to females (p = 0.042), and worse in Whites when compared to Blacks (p = 0.005). For every 10 letters worse in initial VA upon diagnosis with PCV, the final VA was worse by 6 letters (p < 0.001). The location of the polypoidal lesion within the macula was associated with significant decrease of 14 letters in BCVA (p = 0.02). The length of follow up was significantly associated with worse visual outcome (p = 0.012). Final VA had no significant correlation with the lens status, or the different treatment modalities.

conclusionsBased on our cohort from tertiary centers in the United States and United Kingdom, PCV is a bilateral disease in one-fifth of patients. It features a variable female predominance based on ethnicity. Increased age, worse vision upon initial presentation, longer follow up and macular location of the polyp were associated with worse visual outcome.

Indexed as

Fluorescein angiography (FA)Indocyanine green angiography (ICGA)Optical coherence tomography (OCT)Polypoidal choroidal vasculopathy (PCV)

Identifiers

PMID28428893
PMCPMC5392942
OpenAlexW2592006682

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.