ArticleFrontiers in neurology2017
Individualized Repetitive Transcranial Magnetic Stimulation Treatment in Chronic Tinnitus?
Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- RTMS parameters in tinnitus trials: a systematic review.Scientific reports · 2019Pooled it
- Daily high-frequency transcranial random noise stimulation of bilateral temporal cortex in chronic tinnitus - a pilot study.Scientific reports · 2019Trial
- EEG microstates and dynamic functional connectivity reveal stage-specific brain networks in subjective tinnitus.iScience · 2026Article
- Static and Dynamic Changes in Local Brain Connectivity in Unilateral Sudden Sensorineural Hearing Loss.Bioengineering (Basel, Switzerland) · 2025Article
- Anatomo-physiological basis and applied techniques of electrical neuromodulation in chronic pain.Journal of anesthesia, analgesia and critical care · 2024Review
- Personalized Neuromodulation: A Novel Strategy for Improving Tinnitus Treatment.Journal of clinical medicine · 2023Article
- Personalization of Repetitive Transcranial Magnetic Stimulation for the Treatment of Chronic Subjective Tinnitus.Brain sciences · 2022Article
- Case Report: Low-Frequency Repetitive Transcranial Magnetic Stimulation to Dorsolateral Prefrontal Cortex and Auditory Cortex in a Patient With Tinnitus and Depression.Frontiers in psychiatry · 2022Article
- Sequential Prefrontal and Temporoparietal Repetitive Transcranial Magnetic Stimulation (rTMS) for Treatment of Tinnitus With and Without Comorbid Depression: A Case Series and Systematic Review.Frontiers in neurology · 2022Article
- Clinical characteristics of subjective idiopathic tinnitus and preliminarily analyses for the effect of tinnitus multielement integration sound therapy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Heading for Personalized rTMS in Tinnitus: Reliability of Individualized Stimulation Protocols in Behavioral and Electrophysiological Responses.Journal of personalized medicine · 2021Article
- [Improving the role of rTMS and tDCS in the treatment of chronic tinnitus by combining other rehabilitation techniques].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Review
- Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers.Frontiers in aging neuroscience · 2021Review
- Tinnitus and Brain Stimulation.Current topics in behavioral neurosciences · 2021Article
- Animal Models of Tinnitus Treatment: Cochlear and Brain Stimulation.Current topics in behavioral neurosciences · 2021Article
- Altered functional connectivity of the thalamus in tinnitus patients is correlated with symptom alleviation after sound therapy.Brain imaging and behavior · 2020Article
- Non-Invasive Neuromodulation for Tinnitus.Journal of audiology & otology · 2020Review
- The effects of sound therapy in tinnitus are characterized by altered limbic and auditory networks.Brain communications · 2020Article
- Single-Session of Combined tDCS-TMS May Increase Therapeutic Effects in Subjects With Tinnitus.Frontiers in neurology · 2020Article
- Short-Term Tinnitus Suppression With Electric-Field Guided rTMS for Individualizing rTMS Treatment: A Technical Feasibility Report.Frontiers in neurology · 2020Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrefrontal and temporo-parietal repetitive transcranial magnetic stimulation (rTMS) in patients suffering from chronic tinnitus have shown significant but only moderate effectiveness with high interindividual variability in treatment response. This open-label pilot study was designed to examine the general feasibility of an individualized fronto-temporal rTMS protocol and to explore what criteria are needed for a more detailed evaluation in randomized clinical studies.
methodsDuring the first session of a 2-week rTMS protocol, we applied different rTMS protocols to the left and right temporo-parietal and dorsolateral prefrontal cortex (DLPFC) in 25 tinnitus patients. Short trains of 1, 5, 10, and 20 Hz and continuous theta burst stimulation were applied, and patients were asked for immediate tinnitus reductions after each train. If a patient reported such improvements, rTMS treatment was applied over nine sessions with a combined protocol consisting of the most effective frontal and the most effective temporo-parietal stimulation protocol. Those patients who did not improve after the test session were treated with a standard prefrontal plus temporo-parietal protocol (20 Hz over left DLPFC + 1 Hz over temporo-parietal cortex).
resultsAlmost half of the patients (12 of 25) reported immediate tinnitus reductions during the test session. In this group, the mean pre- to post-treatment amelioration in the tinnitus questionnaire was higher (medium to high effect sizes) in contrast to the patients who did not respond to the test session. Treatment outcome remained stable over a follow-up period of 10 weeks. DISCUSSION: Individualized rTMS was shown to be feasible and effective in chronic tinnitus. The results obtained from this study provide tentative evidence in support of an individualized rTMS treatment approach and might provide a basis for a "tailored" application of rTMS in tinnitus and other neuropsychiatric disorders.
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