ArticleWorld journal of gastroenterology2017
Proposed criteria to differentiate heterogeneous eosinophilic gastrointestinal disorders of the esophagus, including eosinophilic esophageal myositis.
Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Eosinophilic esophageal myositis: a comparative study of distinguishing features, diagnostic challenges, and therapeutic insights.Therapeutic advances in gastroenterology · 2026Article
- Eosinophilic esophageal myositis mimicking achalasia: a rare case of dysphagia with extreme LES pressures and histologic clarity.Clinical journal of gastroenterology · 2025Article
- Eosinophilic Esophageal Myositis.ACG case reports journal · 2025Article
- Clinical characteristics of patients with eosinophilic esophagitis and eosinophilic esophageal myositis based on esophageal motility.Esophagus : official journal of the Japan Esophageal Society · 2025Article
- Presence of eosinophils may represent an earlier stage in achalasia pathogenesis.Therapeutic advances in gastroenterology · 2025Article
- Effects of Weizhuan'an on rats with precancerous lesions of gastric cancer based on regulating gastric mucosal microflora and inflammatory factors.Frontiers in pharmacology · 2024Article
- Endoscopic Diagnosis of Eosinophilic Esophagitis: Basics and Recent Advances.Diagnostics (Basel, Switzerland) · 2022Review
- Differences in clinical characteristics between conservative-treatment-response group and refractory (surgical-treatment) group in patients with jackhammer esophagus.Esophagus : official journal of the Japan Esophageal Society · 2021Article
- Symptom-based diagnostic approach for eosinophilic esophagitis.Journal of gastroenterology · 2020Review
- Markedly Effective Steroid Treatment of Three Patients with Allergy-related Jackhammer Esophagus.Internal medicine (Tokyo, Japan) · 2020Article
- Clinical relevance of esophageal subepithelial activity in eosinophilic esophagitis.Journal of gastroenterology · 2020Review
- Oesophageal eosinophilia and oesophageal diseases in children: are the limits clear?BMJ paediatrics open · 2020Review
- Eosinophilic esophagitis: novel concepts regarding pathogenesis and clinical manifestations.Journal of gastroenterology · 2019Review
- Recent advances in dysphagia management.F1000Research · 2019Review
- A case of Jackhammer esophagus caused by eosinophilic esophagitis in which per-oral endoscopic myotomy resulted in symptom improvement.Clinical journal of gastroenterology · 2018Article
- New Eosinophilic Esophagitis Concepts Call for Change in Proton Pump Inhibitor Management Before Diagnostic Endoscopy.Gastroenterology · 2018Article
- Esophageal motility disorders: new perspectives from high-resolution manometry and histopathology.Journal of gastroenterology · 2018Review
- Eosinophilic gastrointestinal disorder: is it what it seems to be?Annals of gastroenterologyArticle
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo define clinical criteria to differentiate eosinophilic gastrointestinal disorder (EoGD) in the esophagus.
methodsOur criteria were defined based on the analyses of the clinical presentation of eosinophilic esophagitis (EoE), subepithelial eosinophilic esophagitis (sEoE) and eosinophilic esophageal myositis (EoEM), identified by endoscopy, manometry and serum immunoglobulin E levels (s-IgE), in combination with histological and polymerase chain reaction analyses on esophageal tissue samples.
resultsIn five patients with EoE, endoscopy revealed longitudinal furrows and white plaques in all, and fixed rings in two. In one patient with sEoE and four with EoEM, endoscopy showed luminal compression only. Using manometry, failed peristalsis was observed in patients with EoE and sEoE with some variation, while EoEM was associated with hypercontractile or hypertensive peristalsis, with elevated s-IgE. Histology revealed the following eosinophils per high-power field values. EoE = 41.4 ± 7.9 in the epithelium and 2.3 ± 1.5 in the subepithelium; sEoE = 3 in the epithelium and 35 in the subepithelium (conventional biopsy); EoEM = none in the epithelium, 10.7 ± 11.7 in the subepithelium (conventional biopsy or endoscopic mucosal resection) and 46.8 ± 16.5 in the muscularis propria (peroral esophageal muscle biopsy). Presence of dilated epithelial intercellular space and downward papillae elongation were specific to EoE. Eotaxin-3, IL-5 and IL-13 were overexpressed in EoE.
conclusionBased on clinical and histological data, we identified criteria, which differentiated between EoE, sEoE and EoEM, and reflected a different pathogenesis between these esophageal EoGDs.
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