ArticleScientific reports2017
Combination of High-density Microelectrode Array and Patch Clamp Recordings to Enable Studies of Multisynaptic Integration.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- An integratediScience · 2026Article
- Advances in large-scale electrophysiology with high-density microelectrode arrays.Lab on a chip · 2025Review
- Review
- Revealing single-neuron and network-activity interaction by combining high-density microelectrode array and optogenetics.Nature communications · 2024Article
- Ensemble learning and ground-truth validation of synaptic connectivity inferred from spike trains.PLoS computational biology · 2024Article
- Beyond a Transmission Cable-New Technologies to Reveal the Richness in Axonal Electrophysiology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Active Micro-Nano-Collaborative Bioelectronic Device for Advanced Electrophysiological Recording.Nano-micro letters · 2024Review
- A Novel 3D Helical Microelectrode Array for In Vitro Extracellular Action Potential Recording.Micromachines · 2022Article
- Article
- Extracellular detection of neuronal coupling.Scientific reports · 2021Article
- Nanotechnology: new opportunities for the development of patch-clamps.Journal of nanobiotechnology · 2021Review
- Building Biomimetic Potency Tests for Islet Transplantation.Diabetes · 2021Review
- Investigation of displacement of intracranial electrode induced by focused ultrasound stimulation.IEEE transactions on instrumentation and measurement · 2021Article
- Assessing the Feasibility of DevelopingFrontiers in neuroscience · 2021Article
- Toward Closed-Loop Electrical Stimulation of Neuronal Systems: A Review.Bioelectricity · 2020Review
- Review
- High-Aspect-Ratio Nanostructured Surfaces as Biological Metamaterials.Advanced materials (Deerfield Beach, Fla.) · 2020Review
- A nanoelectrode array for obtaining intracellular recordings from thousands of connected neurons.Nature biomedical engineering · 2020Article
- Compatibility Evaluation of Clustering Algorithms for Contemporary Extracellular Neural Spike Sorting.Frontiers in systems neuroscience · 2020Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
We present a novel, all-electric approach to record and to precisely control the activity of tens of individual presynaptic neurons. The method allows for parallel mapping of the efficacy of multiple synapses and of the resulting dynamics of postsynaptic neurons in a cortical culture. For the measurements, we combine an extracellular high-density microelectrode array, featuring 11'000 electrodes for extracellular recording and stimulation, with intracellular patch-clamp recording. We are able to identify the contributions of individual presynaptic neurons - including inhibitory and excitatory synaptic inputs - to postsynaptic potentials, which enables us to study dendritic integration. Since the electrical stimuli can be controlled at microsecond resolution, our method enables to evoke action potentials at tens of presynaptic cells in precisely orchestrated sequences of high reliability and minimum jitter. We demonstrate the potential of this method by evoking short- and long-term synaptic plasticity through manipulation of multiple synaptic inputs to a specific neuron.
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Registered trials
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