Evidence map›Paper›PMID 28428547›Full record

ArticleScientific reports2017

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Joshua S Wingerd, Christine A Mozar, Christine A Ussing, Swetha S Murali, Yanni K-Y Chin, Ben Cristofori-Armstrong, Thomas Durek, John Gilchrist, Christopher W Vaughan, Frank Bosmans and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Pain-related toxins in scorpion and spider venoms: a face to face with ion channels.The journal of venomous animals and toxins including tropical diseases · 2021
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Toxins · 2018
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Joshua S WingerdInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.
Christine A MozarDiscipline of Pharmacology, University of Sydney, Camperdown, NSW, 2006, Australia.
Christine A UssingInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.
Swetha S MuraliDiscipline of Pharmacology, University of Sydney, Camperdown, NSW, 2006, Australia.
Yanni K-Y ChinInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.
Ben Cristofori-ArmstrongInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.
Thomas DurekInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.
John GilchristDepartment of Physiology and Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA.
Christopher W VaughanPain Management Research Institute, University of Sydney, St Leonards, NSW, 2006, Australia.ORCID http://orcid.org/0000-0003-4314-7689
Frank BosmansDepartment of Physiology and Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA.
David J AdamsIllawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, 2522, Australia.ORCID http://orcid.org/0000-0002-7030-2288
Richard J LewisInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.
Paul F AlewoodInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.
Mehdi MobliCentre for Advanced Imaging & School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, 4072, Australia.ORCID http://orcid.org/0000-0003-2420-4262
Macdonald J ChristieDiscipline of Pharmacology, University of Sydney, Camperdown, NSW, 2006, Australia.ORCID http://orcid.org/0000-0002-0622-609X
Lachlan D RashInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia. l.rash@uq.edu.au.ORCID http://orcid.org/0000-0003-3616-0279
The University of Queensland · AUThe University of Sydney · AUJohns Hopkins University · USBoston Children's Hospital · USUniversity of Wollongong · AU

Funding

Voltage-gated sodium channel modulation by Beta1 and Beta4 (R01NS091352)R01NS091352 · NINDS · JOHNS HOPKINS UNIVERSITY · PI BOSMANS, FRANK GERT WERNER · 2015 to 2019
$1.3M
The role of auxiliary subunits in the sodium channel signaling complexF31NS084646 · NINDS · JOHNS HOPKINS UNIVERSITY · PI GILCHRIST, JOHN MICHAEL · 2014 to 2016
$129k
NINDS NIH HHS F31 NS084646NINDS NIH HHS R01 NS091352
6 · The paper itself

Abstract

Voltage-gated sodium (Na

Indexed as

AnimalsBinding SitesGene Expression RegulationHEK293 CellsHumansModels, MolecularPeptidesProtein BindingProtein Structure, SecondarySpidersSpider VenomsVoltage-Gated Sodium ChannelsPeptidesSpider VenomsVoltage-Gated Sodium Channels

Identifiers

PMID28428547
PMCPMC5430537
OpenAlexW2607414468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.