ArticleScience (New York, N.Y.)2017
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors.
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In one paragraph
Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,478 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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1,478citing papers in PubMed, 1 pooled it
104.8field-weighted citation impact, top 1% of its field
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Who cites it
1,478 citing papers in PubMed, 1 synthesis or guideline pooled it, 2,436 citations in OpenAlex.
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- Ex vivo-generated conventional dendritic cells type 1 and type 2 from blood progenitors induce potent antigen-specific T-cell immunity.Oncoimmunology · 2026Article
- Bi-directional support of T lymphoma and a lymphoma-associated monocyte population involving Notch signaling in mice.Oncoimmunology · 2026Article
- Identification of SORT1 as a Key Regulator of Antigen Presentation in CD16+ Monocytes During Septic Shock via Multi-Omics and In Silico Gene Knockout Analysis.Immunity, inflammation and disease · 2026Article
- Synovial Fluid Immune Cell Landscape in Juvenile Idiopathic Arthritis.European journal of immunology · 2026Article
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- scGSI: Graph-guided self-supervised integration of paired single-cell multi-omics.PLoS computational biology · 2026Article
- Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells triggers preclinical autoimmunity.Nature immunology · 2026Article
- Comparative Transcriptomic Analysis Reveals Shared Interferon-Associated Transcriptional Programs and Subset-Associated Immune Variation in Human cDC1 and cDC2 Cells Following TLR7 Activation.Cell biochemistry and biophysics · 2026Article
- Tumor-induced dendritic cell deregulation perturbs T cell proliferation and predicts clinical outcome in acute lymphoblastic leukemia.Cell reports. Medicine · 2026Article
- Resolving Immune Lineage and Cell-State Heterogeneity in Human PBMCs via Mass Spectrometry-Based Single-Cell Proteomics.bioRxiv : the preprint server for biology · 2026Article
- High-dimensional profiling following third MMR vaccination or mumps virus infection reveals individuals with suboptimal immunity.Communications medicine · 2026Article
- Organism-scale annotation with Pan-human Azimuth.bioRxiv : the preprint server for biology · 2026Article
- Single-cell analysis of microglia and monocyte dynamics uncovers distinct TNF-driven neuroimmune signatures in humans after intracerebral hemorrhage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
1,418 more citing papers are in PubMed but not listed here.
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Authors and funding
24 authors at 7 institutions in 2 countries.
Alexandra-Chloé VillaniBroad Institute of MIT and Harvard, Cambridge, MA, USA. cvillani@broadinstitute.org m.a.haniffa@newcastle.ac.uk aregev@broadinstitute.org nhacohen@mgh.harvard.edu.ORCID 0000-0001-7461-0408
Rahul SatijaBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-9448-8833
Gary ReynoldsInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0002-8142-8708
Siranush SarkizovaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Karthik ShekharBroad Institute of MIT and Harvard, Cambridge, MA, USA.
James FletcherInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0001-9610-1858
Morgane GriesbeckRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA, USA.ORCID 0000-0003-4962-102X
Andrew ButlerNew York Genome Center, New York University Center for Genomics and Systems Biology, New York, NY, USA.ORCID 0000-0003-3608-0463
Shiwei ZhengNew York Genome Center, New York University Center for Genomics and Systems Biology, New York, NY, USA.ORCID 0000-0001-6682-6743
Suzan LazoDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6678-9847
Laura JardineInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
David DixonInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0003-3346-7160
Emily StephensonInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0002-4244-4019
Emil NilssonOlink Proteomics, Watertown, MA, USA.ORCID 0000-0001-8338-8124
Ida GrundbergOlink Proteomics, Watertown, MA, USA.ORCID 0000-0002-8997-3962
David McDonaldInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0002-2410-9364
Andrew FilbyInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
Weibo LiBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Philip L De JagerBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Orit Rozenblatt-RosenBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Andrew A LaneBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Muzlifah HaniffaInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK. cvillani@broadinstitute.org m.a.haniffa@newcastle.ac.uk aregev@broadinstitute.org nhacohen@mgh.harvard.edu.ORCID 0000-0002-3927-2084
Aviv RegevBroad Institute of MIT and Harvard, Cambridge, MA, USA. cvillani@broadinstitute.org m.a.haniffa@newcastle.ac.uk aregev@broadinstitute.org nhacohen@mgh.harvard.edu.ORCID 0000-0003-3293-3158
Nir HacohenBroad Institute of MIT and Harvard, Cambridge, MA, USA. cvillani@broadinstitute.org m.a.haniffa@newcastle.ac.uk aregev@broadinstitute.org nhacohen@mgh.harvard.edu.ORCID 0000-0002-2349-2656
Broad Institute · USNewcastle University · GBNew York Genome Center · USOlink (United States) · USHarvard University · USRagon Institute of MGH, MIT and Harvard · USRoyal Victoria Infirmary · GB
Funding
The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4MVirology CoreU19AI082630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG, GEORG Michael LAUER · 2009 to 2026
$48.1MPilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MTraining Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8MCenter for Cell CircuitsP50HG006193 · NHGRI · BROAD INSTITUTE, INC. · PI REGEV, AVIV · 2011 to 2015
$15.6MCenter for Cell CircuitsRM1HG006193 · NHGRI · BROAD INSTITUTE, INC. · PI BLAINEY, PAUL CLARK, HACOHEN, NIR · 2016 to 2020
$14.9MLearning the metadata of the cell with single cell genomicsDP2HG009623 · NHGRI · NEW YORK GENOME CENTER · PI SATIJA, RAHUL · 2016 to 2016
$2.8MHoward Hughes Medical InstituteMedical Research Council MR/N005872/1NHGRI NIH HHS DP2 HG009623NHGRI NIH HHS P50 HG006193NHGRI NIH HHS RM1 HG006193NHGRI NIH HHS T32 HG002295NIAID NIH HHS P30 AI060354NIAID NIH HHS U19 AI082630NIDDK NIH HHS P30 DK043351Wellcome Trust
Abstract
Dendritic cells (DCs) and monocytes play a central role in pathogen sensing, phagocytosis, and antigen presentation and consist of multiple specialized subtypes. However, their identities and interrelationships are not fully understood. Using unbiased single-cell RNA sequencing (RNA-seq) of ~2400 cells, we identified six human DCs and four monocyte subtypes in human blood. Our study reveals a new DC subset that shares properties with plasmacytoid DCs (pDCs) but potently activates T cells, thus redefining pDCs; a new subdivision within the CD1C
Indexed as
AdultAntigen PresentationClassificationDendritic CellsFemaleGene Expression ProfilingHumansLymphocyte ActivationMaleMonitoring, ImmunologicMonocytesNeoplasmsSequence Analysis, RNASingle-Cell AnalysisT-LymphocytesTranscriptome
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.