ArticleAJNR. American journal of neuroradiology2017
A Novel MRI Biomarker of Spinal Cord White Matter Injury: T2*-Weighted White Matter to Gray Matter Signal Intensity Ratio.
Article in AJNR. American journal of neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 90 citations in OpenAlex.
- Adult-Lifespan Segment-Specific Normative Atlas of Cervical Spinal Cord Morphology, With Exploratory Application in Degenerative Cervical Myelopathy.Neurospine · 2026Article
- Preoperative dermatomal somatosensory evoked potentials in risk prediction of early postoperative neurological deterioration after thoracic spine surgery: a retrospective cohort study.Journal of orthopaedic surgery and research · 2026Article
- Magnetization transfer MRI (MT-MRI) detects white matter damage beyond the primary site of compression in degenerative cervical myelopathy using a novel semi-automated analysis.Computers in biology and medicine · 2025Article
- Semiautomated Pipeline Effectively Assesses Severity and Monitor Disease Progression in Compressed Spinal Cord of Degenerative Cervical Myelopathy Patients.Neurosurgery practice · 2025Article
- Traumatic spinal cord injury: a review of the current state of art and future directions - what do we know and where are we going?North American Spine Society journal · 2025Article
- Spinal cord gray matter atrophy is associated with disability in spinal muscular atrophy.Journal of neurology · 2025Article
- SCIseg: Automatic Segmentation of Intramedullary Lesions in Spinal Cord Injury on T2-weighted MRI Scans.Radiology. Artificial intelligence · 2025Article
- Parkinson's disease in the spinal cord: An exploratory study to establish T2*w, MTR and diffusion-weighted imaging metric values.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- MRI variables and peripheral inflammatory response biomarkers predict severity and prognosis in patients with acute cervical traumatic spinal cord injury.BMC musculoskeletal disorders · 2024Article
- Cervical spinal cord morphometrics in degenerative cervical myelopathy: quantification using semi-automated normalized technique and correlation with neurological dysfunctions.The spine journal : official journal of the North American Spine Society · 2024Article
- White matter spinal tracts impairment in patients with degenerative cervical myelopathy evaluated with the magnetization transfer saturation MRI technique.Spinal cord · 2024Article
- Advances and Challenges in Spinal Cord Injury Treatments.Journal of clinical medicine · 2024Review
- Updates in current concepts in degenerative cervical myelopathy: a systematic review.Journal of spine surgery (Hong Kong) · 2024Review
- Evaluation of the structural integrity of different spinal cord tracts with magnetization transfer ratio in degenerative cervical myelopathy.Neuroradiology · 2024Article
- Neurodegeneration within the rostral spinal cord is associated with brain gray matter volume atrophy in the early stage of cervical spondylotic myelopathy.Spinal cord · 2024Article
- SCIseg: Automatic Segmentation of T2-weighted Intramedullary Lesions in Spinal Cord Injury.medRxiv : the preprint server for health sciences · 2024Article
- The Prevalence of Asymptomatic Cervical Spinal Cord Compression in Individuals Presenting With Symptomatic Lumbar Spinal Stenosis: A Meta-Analysis.Global spine journal · 2024Review
- Application of the T1w/T2w mapping technique for spinal cord assessment in patients with degenerative cervical myelopathy.Spinal cord · 2024Article
- Evidence-based commentary on the diagnosis, management, and further research of degenerative cervical spinal cord compression in the absence of clinical symptoms of myelopathy.Frontiers in neurology · 2024Review
- A database of the healthy human spinal cord morphometry in the PAM50 template space.Imaging neuroscience (Cambridge, Mass.) · 2024Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeT2*-weighted imaging provides sharp contrast between spinal cord GM and WM, allowing their segmentation and cross-sectional area measurement. Injured WM demonstrates T2*WI hyperintensity but requires normalization for quantitative use. We introduce T2*WI WM/GM signal-intensity ratio and compare it against cross-sectional area, the DTI metric fractional anisotropy, and magnetization transfer ratio in degenerative cervical myelopathy. MATERIALS AND
methodsFifty-eight patients with degenerative cervical myelopathy and 40 healthy subjects underwent 3T MR imaging, covering C1-C7. Metrics were automatically extracted at maximally compressed and uncompressed rostral/caudal levels. Normalized metrics were compared with
resultsThe maximally compressed level cross-sectional area demonstrated superior differences (
conclusionsT2*WI WM/GM shows promise as a novel biomarker of WM injury. It detects damage in compressed and uncompressed regions and contributes substantially to multivariate models for diagnosis and correlation with impairment. Our multiparametric approach overcomes limitations of individual measures, having the potential to improve diagnostics, monitor progression, and predict outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.