Evidence map›Paper›PMID 28428210›Full record

ArticleAJNR. American journal of neuroradiology2017

Proton Chemical Shift Imaging Study of the Combined Antiretroviral Therapy Impact on Neurometabolic Parameters in Chronic HIV Infection.

J Boban, D Kozic, V Turkulov, D Lendak, M Bjelan, M Semnic, S Brkic

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

J BobanFrom the Faculty of Medicine (J.B., D.K., M.B.), University of Novi Sad, Vojvodina Institute of Oncology, Diagnostic Imaging Center, Novi Sad, Serbia jasmina.boban@mf.uns.ac.rs.ORCID http://orcid.org/0000-0001-9701-5484
D KozicFrom the Faculty of Medicine (J.B., D.K., M.B.), University of Novi Sad, Vojvodina Institute of Oncology, Diagnostic Imaging Center, Novi Sad, Serbia.ORCID http://orcid.org/0000-0002-6007-7072
V TurkulovFaculty of Medicine (V.T., D.L., S.B.), University of Novi Sad, Clinical Center of Vojvodina, Clinic for Infectious Diseases, Novi Sad, Serbia.ORCID http://orcid.org/0000-0002-0537-8403
D LendakFaculty of Medicine (V.T., D.L., S.B.), University of Novi Sad, Clinical Center of Vojvodina, Clinic for Infectious Diseases, Novi Sad, Serbia.ORCID http://orcid.org/0000-0003-4323-1776
M BjelanFrom the Faculty of Medicine (J.B., D.K., M.B.), University of Novi Sad, Vojvodina Institute of Oncology, Diagnostic Imaging Center, Novi Sad, Serbia.ORCID http://orcid.org/0000-0002-8957-1816
M SemnicFaculty of Medicine (M.S.), University of Novi Sad, Clinical Center of Vojvodina, Clinic for Neurology, Novi Sad, Serbia.ORCID http://orcid.org/0000-0002-8531-330X
S BrkicFaculty of Medicine (V.T., D.L., S.B.), University of Novi Sad, Clinical Center of Vojvodina, Clinic for Infectious Diseases, Novi Sad, Serbia.ORCID http://orcid.org/0000-0001-9231-7600
University of Novi Sad · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe introduction of combination antiretroviral therapy has failed to reduce the high prevalence of mild forms of HIV-associated neurocognitive disorders. The aim of this study was to test the effect of combined antiretroviral therapy on brain metabolite ratios in chronic HIV infection by using proton chemical shift imaging. MATERIALS AND

methodsWe performed 2D chemical shift imaging in 91 subjects (31 HIV+ patients with chronic infection on combination antiretroviral therapy, 19 combination antiretroviral therapy-naïve HIV+ subjects with chronic infection, and 41 healthy controls), covering frontal and parietal subcortical white and cingulate gyrus gray matter, analyzing ratios of NAA/Cr and Cho/Cr on long-TE and mIns/Cr on short-TE MR spectroscopy. We correlated neurometabolic parameters with immunologic, clinical, data and combined antiretroviral therapy efficacy scores.

resultsThere was a significant decrease in NAA/Cr (

conclusionsThe impact of combined antiretroviral therapy on the process of neuronal loss and dysfunction in chronic HIV infection appears to be suboptimal in successful peripheral suppression of viral replication. Spectroscopic imaging might be a useful tool for monitoring the effects of different combined antiretroviral therapy regimens on brain metabolite ratios.

Indexed as

AdultAnti-HIV AgentsAspartic AcidBrainCholineChronic DiseaseCreatineFemaleHIV InfectionsHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedProtonsAnti-HIV AgentsAspartic AcidCholineCreatineProtons

Identifiers

PMID28428210
PMCPMC7960102
OpenAlexW2605718244

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.