ArticleAJNR. American journal of neuroradiology2017
Myelin Detection Using Rapid Quantitative MR Imaging Correlated to Macroscopically Registered Luxol Fast Blue-Stained Brain Specimens.
Article in AJNR. American journal of neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Can MRI measure myelin? Systematic review, qualitative assessment, and meta-analysis of studies validating microstructural imaging with myelin histology.NeuroImage · 2021Pooled it
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- A DERIVED RELAXATION CONTRAST FROM SYNTHETIC MRI FOR DETECTING NETWORK MICROSTRUCTURAL VULNERABILITY.bioRxiv : the preprint server for biology · 2026Article
- Accelerating myelin defect detection in neurodegenerative disorders: a human-in-the-loop deep learning approach with birefringence microscopy.Neurophotonics · 2025Article
- Electron Density and Effective Atomic Number of Normal-Appearing Adult Brain Tissues: Age-Related Changes and Correlation with Myelin Content.Tomography (Ann Arbor, Mich.) · 2025Article
- Synthetic MRI study of brain volume and subcortical myelin in various Parkinson's disease motor subtypes.NPJ Parkinson's disease · 2025Article
- MRI-based human brain atlases of R1, R2, proton density, and myelin volume fraction using synthetic quantitative imaging at 1.5 T.Journal of neurology · 2025Article
- Association between cardiorespiratory fitness and total brain myelin volume among older adults.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Article
- Neurological disability and brain grey matter atrophy in primary progressive multiple sclerosis are determined by microstructural lesional changes, but not by lesion load.Journal of neurology · 2025Article
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- Evaluation of gray-matter and white-matter microstructural abnormalities in children with growth hormone deficiency: a comprehensive assessment with synthetic magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2025Article
- Fast and reliable quantitative measures of white matter development with magnetic resonance fingerprinting.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Age-stratified Assessment of Brain Volumetric Segmentation on the Indian Population Using Quantitative Magnetic Resonance Imaging.Clinical neuroradiology · 2024Article
- 3D MR fingerprinting-derived myelin water fraction characterizing brain development and leukodystrophy.Journal of translational medicine · 2023Article
- Radiation-dependent demyelination in normal appearing white matter in glioma patients, determined using quantitative magnetic resonance imaging.Physics and imaging in radiation oncology · 2023Article
- Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status.Brain : a journal of neurology · 2023Review
- An automated pipeline for extracting histological stain area fraction for voxelwise quantitative MRI-histology comparisons.NeuroImage · 2022Article
- Synthetic MRI in children with tuberous sclerosis complex.Insights into imaging · 2022Article
- Longitudinal assessment of early-life white matter development with quantitative relaxometry in nonhuman primates.NeuroImage · 2022Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeMyelin detection is of great value in monitoring diseases such as multiple sclerosis and dementia. However, most MR imaging methods to measure myelin are challenging for routine clinical use. Recently, a novel method was published, in which the presence of myelin is inferred by using its effect on the intra- and extracellular water relaxation rates and proton density, observable by rapid quantitative MR imaging. The purpose of this work was to validate this method further on the brains of 12 fresh, intact cadavers. MATERIALS AND
methodsThe 12 brains were scanned with a quantification sequence to determine the longitudinal and transverse relaxation rates and proton density as input for the myelin estimations. Subsequently, the brains were excised at postmortem examination, and brain slices were stained with Luxol fast blue to verify the presence of myelin. The optical density values of photographs of the stained brain slices were registered with the MR images and correlated with the myelin estimation performed by quantitative MR imaging.
resultsA correlation was found between the 2 methods with a mean Spearman ρ for all subjects of 0.74 ± 0.11. Linear regression showed a mean intercept of 1.50% ± 2.84% and a mean slope of 4.37% ± 1.73%/%. A lower correlation was found for the separate longitudinal relaxation rates and proton density (ρ = 0.63 ± 0.12 and -0.73 ± 0.09, respectively). For transverse relaxation rates, the ρ was very low (0.11 ± 0.28).
conclusionsThe observed correlation supports the validity of myelin measurement by using the MR imaging quantification method.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.