Evidence map›Paper›PMID 28428205›Full record

ArticleAJNR. American journal of neuroradiology2017

Measurable Supratentorial White Matter Volume Changes in Patients with Diffuse Intrinsic Pontine Glioma Treated with an Anti-Vascular Endothelial Growth Factor Agent, Steroids, and Radiation.

P Svolos, W E Reddick, A Edwards, A Sykes, Y Li, J O Glass, Z Patay

Open access · hybridAbstract readClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

P SvolosFrom the Departments of Diagnostic Imaging (P.S., W.E.R., A.E., J.O.G., Z.P.).ORCID http://orcid.org/0000-0001-6706-2933
W E ReddickFrom the Departments of Diagnostic Imaging (P.S., W.E.R., A.E., J.O.G., Z.P.).ORCID http://orcid.org/0000-0002-1054-1201
A EdwardsFrom the Departments of Diagnostic Imaging (P.S., W.E.R., A.E., J.O.G., Z.P.).ORCID http://orcid.org/0000-0003-2979-5508
A SykesBiostatistics (A.S., Y.L.), St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID http://orcid.org/0000-0002-7667-8155
Y LiBiostatistics (A.S., Y.L.), St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID http://orcid.org/0000-0002-7046-4316
J O GlassFrom the Departments of Diagnostic Imaging (P.S., W.E.R., A.E., J.O.G., Z.P.).ORCID http://orcid.org/0000-0001-9679-2054
Z PatayFrom the Departments of Diagnostic Imaging (P.S., W.E.R., A.E., J.O.G., Z.P.) zoltan.patay@stjude.org.ORCID http://orcid.org/0000-0003-1479-9864
Imaging Center · USSt. Jude Children's Research Hospital · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
NCI NIH HHS P30 CA021765
6 · The paper itself

Abstract

background and purposeAssessing the response to treatment in infiltrative brain tumors by using lesion volume-based response criteria is challenging. We hypothesized that in such tumors, volume measurements alone may not accurately capture changes in actual tumor burden during treatment. We longitudinally evaluated volume changes in both normal-appearing supratentorial white matter and the brain stem lesions in patients treated for diffuse intrinsic pontine glioma to determine to what extent adjuvant systemic therapies may skew the accuracy of tumor response assessments based on volumetric analysis. MATERIALS AND

methodsThe anatomic MR imaging and diffusion tensor imaging data of 26 patients with diffuse intrinsic pontine glioma were retrospectively analyzed. Treatment included conformal radiation therapy in conjunction with vandetanib and dexamethasone. Volumetric and diffusion data were analyzed with time, and differences between time points were evaluated statistically.

resultsNormalized brain stem lesion volume decreased during combined treatment (slope = -0.222,

conclusionsLongitudinal changes in brain stem lesion volume are robust; less pronounced but measurable changes occur in the supratentorial white matter. Volume changes in nonirradiated supratentorial white matter during the disease course reflect the effects of systemic medication on the water homeostasis of normal parenchyma. Our data suggest that adjuvant nontumor-targeted therapies may have a more substantial effect on lesion volume changes than previously thought; hence, an apparent volume decrease in infiltrative tumors receiving combined therapies may lead to overestimation of the actual response and tumor control.

Indexed as

Antineoplastic AgentsBrain StemBrain Stem NeoplasmsChildChild, PreschoolCombined Modality TherapyDexamethasoneDiffusion Tensor ImagingDisease-Free SurvivalDisease ProgressionFemaleGliomaHumansMagnetic Resonance ImagingMalePiperidinesAntineoplastic AgentsDexamethasonePiperidinesQuinazolinesSteroidsvandetanibVascular Endothelial Growth Factor A

Identifiers

PMID28428205
PMCPMC5471144
OpenAlexW2606536127

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.