Evidence map›Paper›PMID 28428187›Full record

Trial reportBMJ open2017

Zambian Peer Educators for HIV Self-Testing (ZEST) study: rationale and design of a cluster randomised trial of HIV self-testing among female sex workers in Zambia.

Catherine E Oldenburg, Katrina F Ortblad, Michael M Chanda, Kalasa Mwanda, Wendy Nicodemus, Rebecca Sikaundi, Andrew Fullem, Leah G Barresi, Guy Harling, Till Bärnighausen

Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02827240 (A Peer Educator-delivered HIV Self-testing Intervention for Female Sex Workers in Zambian Border Towns), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
11.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02827240 nacompletednot on this map

A Peer Educator-delivered HIV Self-testing Intervention for Female Sex Workers in Zambian Border Towns

TypeinterventionalSponsorHarvard School of Public Health (HSPH)Ran2016 to 2017Enrolled965ConditionsHIV InfectionArmsOral HIV Self-Testing
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

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  10. Scaling Up HIV Self-Testing and Linkage to Care Among Women Who Exchange Sex and/or Use Drugs in Kazakhstan.AIDS education and prevention : official publication of the International Society for AIDS Education · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Catherine E OldenburgDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Katrina F OrtbladDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Michael M ChandaJohn Snow, Inc, Lusaka, Zambia.
Kalasa MwandaJohn Snow, Inc, Lusaka, Zambia.
Wendy NicodemusJohn Snow, Inc, Lusaka, Zambia.
Rebecca SikaundiJohn Snow, Inc, Lusaka, Zambia.
Andrew FullemJohn Snow, Inc, Boston, Massachusetts, USA.
Leah G BarresiDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Guy HarlingDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Till BärnighausenDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Harvard Global Health Institute · USAfrica Health Research Institute · ZAHarvard University · USJohn Snow (United States) · USSan Francisco Foundation · US

Funding

HIV and Other Infectious Consequences of Substance UseT32DA013911 · NIDA · MIRIAM HOSPITAL · PI TRACI C GREEN, JOSIAH D RICH · 2001 to 2026
$9.6M
Epidemiology of Infectious Diseases and BiodefenseT32AI007535 · NIAID · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI GRAD, YONATAN H, MURRAY, MEGAN B · 1998 to 2025
$4.8M
The Brown Initiative in HIV and AIDS Clinical Research for Minority CommunitiesR25MH083620 · NIMH · MIRIAM HOSPITAL · PI NUNN, AMY STEWART · 2008 to 2025
$3.7M
New Methods for the design and evaluation of large HIV prevention interventionsR01AI112339 · NIAID · YALE UNIVERSITY · PI SPIEGELMAN, DONNA L · 2014 to 2017
$2.7M
Causal Pathways to population health impact of HIV antiretroviral treatmentR01HD084233 · NICHD · UNIVERSITY OF KWAZULU-NATAL · PI BARNIGHAUSEN, TILL, TANSER, FRANK COURTENEY · 2015 to 2021
$2.3M
Can HIV Hot-Spots be eradicated? An intervention to decrease HIV transmission to young women in rural KwaZulu-Natal South AfricaR01AI124389 · NIAID · UNIVERSITY OF KWAZULU-NATAL · PI BARNIGHAUSEN, TILL, TANSER, FRANK COURTENEY · 2016 to 2020
$2.1M
NIAID NIH HHS R01 AI112339NIAID NIH HHS R01 AI124389NIAID NIH HHS T32 AI007535NICHD NIH HHS R01 HD084233NIDA NIH HHS T32 DA013911NIMH NIH HHS R25 MH083620
6 · The paper itself

Abstract

backgroundHIV testing and knowledge of status are starting points for HIV treatment and prevention interventions. Among female sex workers (FSWs), HIV testing and status knowledge remain far from universal. HIV self-testing (HIVST) is an alternative to existing testing services for FSWs, but little evidence exists how it can be effectively and safely implemented. Here, we describe the rationale and design of a cluster randomised trial designed to inform implementation and scale-up of HIVST programmes for FSWs in Zambia.

methodsThe Zambian Peer Educators for HIV Self-Testing (ZEST) study is a 3-arm cluster randomised trial taking place in 3 towns in Zambia. Participants (N=900) are eligible if they are women who have exchanged sex for money or goods in the previous 1 month, are HIV negative or status unknown, have not tested for HIV in the previous 3 months, and are at least 18 years old. Participants are recruited by peer educators working in their communities. Participants are randomised to 1 of 3 arms: (1) direct distribution (in which they receive an HIVST from the peer educator directly); (2) fixed distribution (in which they receive a coupon with which to collect the HIVST from a drug store or health post) or (3) standard of care (referral to existing HIV testing services only, without any offer of HIVST). Participants are followed at 1 and 4 months following distribution of the first HIVST. The primary end point is HIV testing in the past month measured at the 1-month and 4-month visits. ETHICS AND DISSEMINATION: This study was approved by the Institutional Review Boards at the Harvard T.H. Chan School of Public Health in Boston, USA and ERES Converge in Lusaka, Zambia. The findings of this trial will be presented at local, regional and international meetings and submitted to peer-reviewed journals for publication. TRIAL REGISTRATION NUMBER: Pre-results; NCT02827240.

Indexed as

Community Health WorkersAdultCluster AnalysisFeasibility StudiesFemaleHealth Knowledge, Attitudes, PracticeHIV InfectionsHumansMass ScreeningPatient Acceptance of Health CareProgram EvaluationSerologic TestsSex WorkersSocial StigmaZambiafemale sex workersHIV self-testingHIV testingSub-Saharan Africa

Identifiers

PMID28428187
PMCPMC5775452
OpenAlexW2606155774

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.