Evidence map›Paper›PMID 28428045›Full record

ArticleMolecular and cellular endocrinology2017

Sco2 deficient mice develop increased adiposity and insulin resistance.

Shauna Hill, Sathyaseelan S Deepa, Kavithalakshmi Sataranatarajan, Pavithra Premkumar, Daniel Pulliam, Yuhong Liu, Vanessa Y Soto, Kathleen E Fischer, Holly Van Remmen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Defect ofInternational journal of molecular sciences · 2023
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Metabolic adventures in aging research.Molecular and cellular endocrinology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Shauna HillAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK 73104, United States; Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States.
Sathyaseelan S DeepaAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK 73104, United States.
Kavithalakshmi SataranatarajanAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK 73104, United States.
Pavithra PremkumarAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK 73104, United States.
Daniel PulliamAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK 73104, United States; Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States.
Yuhong LiuDepartment of Biology, University of Alabama at Birmingham, 1720 2nd Avenue South, CH 464, Birmingham, AL 35294, United States.
Vanessa Y SotoDepartment of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States.
Kathleen E FischerDepartment of Biology, University of Alabama at Birmingham, 1720 2nd Avenue South, CH 464, Birmingham, AL 35294, United States.
Holly Van RemmenAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK 73104, United States; Oklahoma City VA Medical Center, Oklahoma City, OK, United States. Electronic address: Holly-VanRemmen@omrf.org.
Oklahoma Medical Research Foundation · USThe University of Texas Health Science Center at San Antonio · USUniversity of Alabama at Birmingham · US

Funding

A novel role for mitochondrial dysfunction in mitochondrial signalingF31AG047764 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HILL, SHAUNA · 2014 to 2016
$84k
Testing the mechanisms by which NMJ disruption contributes to sarcopeniaI01BX002595 · VA · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · PI VAN REMMEN, HOLLY · 2015 to 2017
–
BLRD VA I01 BX002595NIA NIH HHS F31 AG047764
6 · The paper itself

Abstract

Cytochrome c oxidase (COX) is an essential transmembrane protein complex (Complex IV) in the mitochondrial respiratory electron chain. Mutations in genes responsible for the assembly of COX are associated with Leigh syndrome, cardiomyopathy, spinal muscular atrophy and other fatal metabolic disorders in humans. Previous studies have shown that mice lacking the COX assembly protein Surf1 (Surf1

Indexed as

Gene DeletionAdipogenesisAdipose TissueAdiposityAnimalsCholesterolElectron Transport Complex IVFatty LiverGene Expression RegulationGlucose Transporter Type 4Insulin ResistanceMaleMiceMice, KnockoutMitochondriaMolecular ChaperonesCholesterolElectron Transport Complex IVGlucose Transporter Type 4Molecular ChaperonesReceptor, InsulinSCO2 protein, mouseSlc2a4 protein, mouseTriglyceridesAdipose tissueComplex IVInsulin resistanceMitochondriaSco2

Identifiers

PMID28428045
PMCPMC5592144
OpenAlexW2606795822

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.