Evidence map›Paper›PMID 28427989›Full record

ArticleNeuropsychologia2017

Egocentric and allocentric visuospatial working memory in premotor Huntington's disease: A double dissociation with caudate and hippocampal volumes.

Katherine L Possin, Hosung Kim, Michael D Geschwind, Tacie Moskowitz, Erica T Johnson, Sharon J Sha, Alexandra Apple, Duan Xu, Bruce L Miller, Steven Finkbeiner and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Review
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  5. Humanized dopamine DJournal of neuroscience research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Katherine L PossinDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA; Hellman Family Foundation Alzheimer's Disease Research Program, San Francisco, California, USA. Electronic address: Katherine.Possin@ucsf.edu.
Hosung KimDepartment of Radiology, University of California, San Francisco, USA.
Michael D GeschwindDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Tacie MoskowitzDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Erica T JohnsonDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Sharon J ShaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Alexandra AppleDepartment of Radiology, University of California, San Francisco, USA.
Duan XuDepartment of Radiology, University of California, San Francisco, USA.
Bruce L MillerDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Steven FinkbeinerHellman Family Foundation Alzheimer's Disease Research Program, San Francisco, California, USA; Gladstone Institute of Neurological Disease, San Francisco, CA, USA; Departments of Neurology and Physiology, University of California, San Francisco, CA, USA; Keck Program in Brain Cell Engineering, Gladstone Institutes, San Francisco, CA, USA; Taube/Koret Center for Neurodegenerative Disease Research, San Francisco, CA, USA; Roddenberry Stem Cell Program, San Francisco, CA, USA.
Christopher P HessDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA; Department of Radiology, University of California, San Francisco, USA.
Joel H KramerDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.

Funding

Transgenic Mouse Models of Tau PathologiesP01AG017586 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, VIRGINIA M · 2000 to 2021
$37.3M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
Mechanisms of Executive Decline in Normal AgingR01AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaitlin B Casaletto, JOEL H KRAMER · 2009 to 2026
$8.3M
Mechanisms of Spatial Cognitive Impairment in Neurodegenerative DiseaseK23AG037566 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POSSIN, KATHERINE LAUREL · 2011 to 2015
$697k
NCRR NIH HHS L30 RR024974NIA NIH HHS K23 AG037566NIA NIH HHS P01 AG017586NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG032289NIBIB NIH HHS P41 EB015922
6 · The paper itself

Abstract

Our brains represent spatial information in egocentric (self-based) or allocentric (landmark-based) coordinates. Rodent studies have demonstrated a critical role for the caudate in egocentric navigation and the hippocampus in allocentric navigation. We administered tests of egocentric and allocentric working memory to individuals with premotor Huntington's disease (pmHD), which is associated with early caudate nucleus atrophy, and controls. Each test had 80 trials during which subjects were asked to remember 2 locations over 1-sec delays. The only difference between these otherwise identical tests was that locations could only be coded in self-based or landmark-based coordinates. We applied a multiatlas-based segmentation algorithm and computed point-wise Jacobian determinants to measure regional variations in caudate and hippocampal volumes from 3T MRI. As predicted, the pmHD patients were significantly more impaired on egocentric working memory. Only egocentric accuracy correlated with caudate volumes, specifically the dorsolateral caudate head, right more than left, a region that receives dense efferents from dorsolateral prefrontal cortex. In contrast, only allocentric accuracy correlated with hippocampal volumes, specifically intermediate and posterior regions that connect strongly with parahippocampal and posterior parietal cortices. These results indicate that the distinction between egocentric and allocentric navigation applies to working memory. The dorsolateral caudate is important for egocentric working memory, which can explain the disproportionate impairment in pmHD. Allocentric working memory, in contrast, relies on the hippocampus and is relatively spared in pmHD.

Indexed as

Memory, Short-TermSelf ConceptSocial PerceptionAdultAlgorithmsAnalysis of VarianceCaudate NucleusFemaleHippocampusHumansHuntington DiseaseImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsCaudateNavigationVisuospatialWorking memory

Identifiers

PMID28427989
PMCPMC5765862

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.