ArticleBrain, behavior, and immunity2017
Safety parameter considerations of anodal transcranial Direct Current Stimulation in rats.
Article in Brain, behavior, and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Memory and Cognition-Related Neuroplasticity Enhancement by Transcranial Direct Current Stimulation in Rodents: A Systematic Review.Neural plasticity · 2020Pooled it
- Strategies to implement and monitor in-home transcranial electrical stimulation in neurological and psychiatric patient populations: a systematic review.Journal of neuroengineering and rehabilitation · 2019Pooled it
- Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines (2017-2025: An update) - endorsed by the European Society for Brain Stimulation (ESBS) and by the International Federation for Clinical Neurophysiology (IFCN).Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Somatodendritic orientation determines tDCS-induced neuromodulation of Purkinje cell activity in awake mice.eLife · 2025Article
- Safety of ipsilesional anodal transcranial direct current stimulation in acute photothrombotic stroke: implications for early neurorehabilitation.Scientific reports · 2024Article
- Brain complexity in stroke recovery after bihemispheric transcranial direct current stimulation in mice.Brain communications · 2024Article
- Safety and Tolerability of tDCS across Different Ages, Sexes, Diagnoses, and Amperages: A Randomized Double-Blind Controlled Study.Journal of clinical medicine · 2023Article
- Electric Fields Induced in the Brain by Transcranial Electric Stimulation: A Review of In Vivo Recordings.Biomedicines · 2022Review
- Safety of Special Waveform of Transcranial Electrical Stimulation (TES): In Vivo Assessment.International journal of molecular sciences · 2022Article
- Transcranial direct current stimulation (tDCS) reduces motivation to drink ethanol and reacquisition of ethanol self-administration in female mice.Scientific reports · 2022Article
- Direct Current Stimulation Disrupts Endothelial Glycocalyx and Tight Junctions of the Blood-Brain BarrierFrontiers in cell and developmental biology · 2021Article
- Modulation of solute diffusivity in brain tissue as a novel mechanism of transcranial direct current stimulation (tDCS).Scientific reports · 2020Article
- Allele-Specific PCR forDiagnostics (Basel, Switzerland) · 2020Article
- Therapeutic effects of anodal transcranial direct current stimulation in a rat model of ADHD.eLife · 2020Article
- Intracranial alternating current stimulation facilitates neurogenesis in a mouse model of Alzheimer's disease.Alzheimer's research & therapy · 2020Article
- Regenerative Rehabilitation for Stroke Recovery by Inducing Synergistic Effects of Cell Therapy and Neurorehabilitation on Motor Function: A Narrative Review of Pre-Clinical Studies.International journal of molecular sciences · 2020Review
- In Vivo Modulation of the Blood-Brain Barrier Permeability by Transcranial Direct Current Stimulation (tDCS).Annals of biomedical engineering · 2020Article
- Plasma BDNF Levels Following Transcranial Direct Current Stimulation Allow Prediction of Synaptic Plasticity and Memory Deficits in 3×Tg-AD Mice.Frontiers in cell and developmental biology · 2020Article
- Safety Aspects, Tolerability and Modeling of Retinofugal Alternating Current Stimulation.Frontiers in neuroscience · 2019Article
- Non-invasive Brain Stimulation in Pediatric Migraine: A Perspective From Evidence in Adult Migraine.Frontiers in neurology · 2019Review
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Authors and funding
7 authors.
Funding
Abstract
A commonly referenced transcranial Direct Current Stimulation (tDCS) safety threshold derives from tDCS lesion studies in the rat and relies on electrode current density (and related electrode charge density) to support clinical guidelines. Concerns about the role of polarity (e.g. anodal tDCS), sub-lesion threshold injury (e.g. neuroinflammatory processes), and role of electrode montage across rodent and human studies support further investigation into animal models of tDCS safety. Thirty-two anesthetized rats received anodal tDCS between 0 and 5mA for 60min through one of three epicranial electrode montages. Tissue damage was evaluated using hemotoxylin and eosin (H&E) staining, Iba-1 immunohistochemistry, and computational brain current density modeling. Brain lesion occurred after anodal tDCS at and above 0.5mA using a 25.0mm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.