Evidence map›Paper›PMID 28427861›Full record

ArticleThe American journal of pathology2017

Divergent Function of Programmed Death-Ligand 1 in Donor Tissue versus Recipient Immune System in a Murine Model of Bronchiolitis Obliterans.

Katharina Schütte-Nütgen, Olaf Boenisch, Hakima Harrach, Alicia Casey, Indira Guleria, Nader Najafian, Mohamed H Sayegh, Craig J Gerard, Meera Subramaniam

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Katharina Schütte-NütgenPulmonary Division, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Internal Medicine D, University Hospital Münster, Münster, Germany.
Olaf BoenischTransplantation Research Center, Brigham and Women's Hospital and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.
Hakima HarrachPulmonary Division, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Alicia CaseyPulmonary Division, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Indira GuleriaTransplantation Research Center, Brigham and Women's Hospital and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Nader NajafianTransplantation Research Center, Brigham and Women's Hospital and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Mohamed H SayeghMedical Faculty, American University of Beirut, Beirut, Lebanon.
Craig J GerardPulmonary Division, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Meera SubramaniamPulmonary Division, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: meera.subramaniam@childrens.harvard.edu.
Boston Children's Hospital · USBrigham and Women's Hospital · USAmerican University of Beirut · LB

Funding

Matrix Metalloproteinase-8 in Obliterative Bronchiolitis Post Lung TransplantK08HL084242 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI SUBRAMANIAM, MEERA · 2006 to 2010
$661k
NHLBI NIH HHS K08 HL084242
6 · The paper itself

Abstract

Costimulatory molecules, such as the programmed death ligand (PD-L1), might exert differential effects on T-cell function, depending on the clinical setting and/or immunological environment. Given the impact of T cells on bronchiolitis obliterans (BO) in lung transplantation, we used an established tracheal transplant model inducing BO-like lesions to investigate the impact of PD-L1 on alloimmune responses and histopathological outcome in BO. In contrast to other transplant models in which PD-L1 generally shows protective functions, we demonstrated that PD-L1 has divergent effects depending on its location in donor versus recipient tissue. Although PD-L1 deficiency in donor tissue worsened histopathological outcome, and increased systemic inflammatory response, recipient PD-L1 deficiency induced opposite effects. Mechanistic studies revealed PD-L1-deficient recipients were hyporesponsive toward alloantigen, despite increased numbers of CD8

Indexed as

Transplantation ImmunologyAnimalsB7-H1 AntigenBronchiolitis ObliteransCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDisease Models, AnimalEpithelial CellsGraft SurvivalImmune ToleranceImmunity, CellularIsoantigensLymphocyte ActivationMice, Inbred BALB CMice, Inbred C57BLTissue DonorsB7-H1 AntigenCd274 protein, mouseIsoantigens

Identifiers

PMID28427861
PMCPMC5455059
OpenAlexW2606865703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.