ArticleInternational journal of cardiology2017
Five-year changes in cardiac structure and function in patients with rheumatoid arthritis compared with the general population.
Article in International journal of cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Preclinical cardiac organ damage during statin treatment in patients with inflammatory joint diseases: the RORA-AS statin intervention study.Rheumatology (Oxford, England) · 2020Trial
- Inflammation and the Heart: The Role of Traditional Factors.Cardiology research and practice · 2026Review
- Factors associated with left ventricular mass during disease modifying antirheumatic drug therapy in patients with rheumatoid arthritis: the Joint Heart study.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Myocardial fibrosis, the silent instigator of diastolic dysfunction in patients with rheumatoid arthritis.Physiological research · 2025Review
- Insights into Pulmonary Arterial Hypertension in Connective Tissue Diseases.Journal of clinical medicine · 2025Review
- Evaluation of the Cardiac Effects of Inflammation in Patients with Rheumatoid Arthritis and Spondyloarthritis.The Eurasian journal of medicine · 2025Article
- The importance of speckle tracking echocardiography in the evaluation of cardiac functions in patients with rheumatoid arthritis.Archives of rheumatology · 2024Article
- Rheumatoid arthritis increases the risk of heart failure: results from the cross-sectional study in the US population and mendelian randomization analysis in the European population.Frontiers in immunology · 2024Article
- Epicardial adipose tissue in patients with systemic sclerosis.European heart journal. Imaging methods and practice · 2023Article
- Left ventricular remodeling in rheumatoid arthritis patients without clinical heart failure.Arthritis research & therapy · 2023Article
- Rheumatoid arthritis increases the risk of heart failure-current evidence from genome-wide association studies.Frontiers in endocrinology · 2023Article
- Genetically Determined Rheumatoid Arthritis May Not Affect Heart Failure: Insights from Mendelian Randomization Study.Global heart · 2023Article
- Increased Risk of Cardiovascular Diseases in Rheumatoid Arthritis: A Systematic Review.Cureus · 2022Review
- Citrullination is linked to reduced CaActa physiologica (Oxford, England) · 2022Article
- Prospective changes in diastolic function in patients with rheumatoid arthritis.Arthritis research & therapy · 2022Article
- Myocardial Dysfunction and Heart Failure in Rheumatoid Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2022Review
- Autoimmune Rheumatic Diseases and Vascular Function: The Concept of Autoimmune Atherosclerosis.Journal of clinical medicine · 2021Review
- Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Review
- Exercise protects against cardiac and skeletal muscle dysfunction in a mouse model of inflammatory arthritis.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundPatients with rheumatoid arthritis (RA) have increased risk of heart failure with preserved ejection fraction. The development and progression of left ventricular dysfunction before onset of clinical heart failure are unknown. The objective of this study was to evaluate longitudinal changes in cardiac structure and function of patients with RA compared with persons in the general population.
methodsA prospective longitudinal study of a population-based cohort of 160 patients with RA and a population-based cohort of 1391 persons without RA (non-RA cohort) was performed. Each participant underwent 2-dimensional, pulsed-wave tissue Doppler echocardiography at baseline and after 4 to 5years of follow-up. Age- and sex-adjusted linear regression models were used to test for differences between the RA and non-RA cohorts in annualized rates of change for echocardiographic parameters.
resultsMitral A velocity increased more rapidly among the patients with RA than the non-RA cohort (age- and sex-adjusted parameter estimate, 0.030; P<0.001). Correspondingly, the mean mitral inflow E/A ratio decreased faster in the RA cohort than the non-RA cohort (adjusted parameter estimate, -0.096; P<0.001). The left atrial volume index increased at a higher rate in the RA cohort than the non-RA cohort (adjusted parameter estimate, 0.150; P<0.001).
conclusionsThis pattern of echocardiographic findings confirms previous cross-sectional studies and indicates that subclinical changes in diastolic function occur more rapidly over 5years in RA patients than in the general population. Further research into the mechanisms of myocardial disease in these patients and the relationship with disease activity and treatment is warranted.
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