ArticleParasites & vectors2017
Benchmarking insecticide resistance intensity bioassays for Anopheles malaria vector species against resistance phenotypes of known epidemiological significance.
Article in Parasites & vectors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Evidence of microbiome contribution to the escalation of pyrethroid resistance in the major malaria vectors Anopheles gambiae s.s. and Anopheles funestus s.s.BMC microbiology · 2025Article
- Spatial-temporal vector abundance and malaria transmission dynamics in Nchelenge and Lake Mweru islands, a region with a high burden of malaria in northern Zambia.Malaria journal · 2023Article
- Characterising the intensity of insecticide resistance: A novel framework for analysis of intensity bioassay data.Current research in parasitology & vector-borne diseases · 2023Article
- Intensity of insecticide resistance in the major malaria vector Anopheles funestus from Chikwawa, rural Southern Malawi.Parasites & vectors · 2022Article
- Using ecological observations to improve malaria control in areas where Anopheles funestus is the dominant vector.Malaria journal · 2022Review
- The effect of blood feeding on insecticide resistance intensity and adult longevity in the major malaria vector Anopheles funestus (Diptera: Culicidae).Scientific reports · 2022Article
- The in silico and in vitro analysis of donepezil derivatives for Anopheles acetylcholinesterase inhibition.PloS one · 2022Article
- First Report on Intensity Bioassays for Pyrethroid Resistance inJournal of tropical medicine · 2022Article
- Review
- Use of alternative bioassays to explore the impact of pyrethroid resistance on LLIN efficacy.Parasites & vectors · 2020Article
- Absence of knockdown mutations in pyrethroid and DDT resistant populations of the main malaria vectors in Colombia.Malaria journal · 2019Article
- Second WIN International Conference on "Integrated approaches and innovative tools for combating insecticide resistance in vectors of arboviruses", October 2018, Singapore.Parasites & vectors · 2019Article
- High insecticide resistance intensity of Anopheles gambiae (s.l.) and low efficacy of pyrethroid LLINs in Accra, Ghana.Parasites & vectors · 2019Article
- Article
- Study of the epidemiological behavior of malaria in the Darien Region, Panama. 2015-2017.PloS one · 2019Article
- The impact of temperature on insecticide toxicity against the malaria vectors Anopheles arabiensis and Anopheles funestus.Malaria journal · 2018Article
- Empirical and theoretical investigation into the potential impacts of insecticide resistance on the effectiveness of insecticide-treated bed nets.Evolutionary applications · 2018Article
- Pyrethroids resistance intensity and resistance mechanisms in Anopheles gambiae from malaria vector surveillance sites in Nigeria.PloS one · 2018Article
- Insecticide Resistance and Its Intensity in Populations of Malaria Vectors in Colombia.BioMed research international · 2018Article
- Closing the barrier between disease and health outcomes in Africa through research and capacity development.Global health action · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundInsecticide use via indoor residual spraying (IRS) or treated nets is the primary method for controlling malaria vector populations. The incidence of insecticide resistance in vector populations is burgeoning globally making resistance management key to the design of effective malaria control and elimination strategies. Vector populations can be assessed for insecticide resistance using a binary (susceptible or resistant) classification based on the use of the standard WHO insecticide susceptibility assay for adult anopheline mosquitoes. However, the recent scaling up of vector control activities has necessitated a revision of the WHO bioassay protocol to include the production of information that not only diagnoses resistance but also gives information on the intensity of expression of resistance phenotypes detected. This revised protocol is expected to inform on the range of resistance phenotypes in a target vector population using discriminating/diagnostic insecticide concentrations (DC) as well as their potential operational significance using 5× DC and 10× DC assays. The aim of this project was to use the revised protocol to assess the intensity of pyrethroid resistance in a range of insecticide resistant Anopheles strains with known resistance mechanisms and for which there is evidence of operational significance in the field setting from which these colonies were derived.
methodsDiagnostic concentration (DC) bioassays followed by 5× DC and 10× DC assays using the pyrethroid insecticides permethrin and deltamethrin were conducted according to the standard WHO bioassay method against pyrethroid resistant laboratory strains of Anopheles funestus, An. arabiensis and An. gambiae.
resultsLow to moderate resistance intensities were recorded for the An. arabiensis and An. gambiae strains while moderate to high intensities were recorded for the An. funestus strains.
conclusionsIt is evident that resistance intensity assays can add predictive value to the decision making process in vector control settings, although more so in an IRS setting and especially when bench-marked against resistance phenotypes of known operational significance.
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