ReviewCardiovascular diabetology2017
Is ischemia the only factor predicting cardiovascular outcomes in all diabetes mellitus patients?
Review in Cardiovascular diabetology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
- Long-term outcomes of patients with normal fractional flow reserve and thin-cap fibroatheroma.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2023Trial
- Predictors of Short- and Long-Term Major Adverse Cardiac and Cerebrovascular Events (MACCE) After Percutaneous Coronary Intervention: A Cohort Study on the Data of National Persian Registry of Cardiovascular Disease (N-PROVE).Health science reports · 2026Article
- Ten-year predictors of major adverse cardiovascular events in patients without angina.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2023Article
- Exploring new insights in coronary lesion assessment and treatment in patients with diabetes mellitus: the impact of optical coherence tomography.Cardiovascular diabetology · 2023Review
- Current Role of Intracoronary Imaging for Implementing Risk Stratification and Tailoring Culprit Lesion Treatment: A Narrative Review.Journal of clinical medicine · 2023Review
- Identification of vulnerable non-culprit lesions by coronary computed tomography angiography in patients with chronic coronary syndrome and diabetes mellitus.Frontiers in cardiovascular medicine · 2023Article
- Diabetic heart disease: A clinical update.World journal of diabetes · 2021Review
- Traditional Cardiovascular Risk Factors and Coronary Collateral Circulation: A Meta-Analysis.Frontiers in cardiovascular medicine · 2021Article
- Intra-coronary Imaging for the Evaluation of Plaque Modifications Induced by Drug Therapies for Secondary Prevention.Current atherosclerosis reports · 2020Review
- Searching for optimal blood pressure targets in type 2 diabetic patients with coronary artery disease.Cardiovascular diabetology · 2019Review
- Relationships of coronary culprit-plaque characteristics with duration of diabetes mellitus in acute myocardial infarction: an intravascular optical coherence tomography study.Cardiovascular diabetology · 2019Article
- Serial coronary computed tomography angiography-verified coronary plaque progression: comparison of stented patients with or without diabetes.Cardiovascular diabetology · 2019Article
- Successful revascularization versus medical therapy in diabetic patients with stable right coronary artery chronic total occlusion: a retrospective cohort study.Cardiovascular diabetology · 2019Article
- Lipoprotein (a) interactions with cholesterol-containing lipids on angiographic coronary collateralization in type 2 diabetic patients with chronic total occlusion.Cardiovascular diabetology · 2019Article
- Development of predictive risk models for major adverse cardiovascular events among patients with type 2 diabetes mellitus using health insurance claims data.Cardiovascular diabetology · 2018Observational
- Revascularization in stable coronary disease: evidence and uncertainties.Nature reviews. Cardiology · 2018Review
- Donor artery stenosis interactions with diastolic blood pressure on coronary collateral flow in type 2 diabetic patients with chronic total occlusion.Cardiovascular diabetology · 2018Article
- Reduced coronary collateralization in type 2 diabetic patients with chronic total occlusion.Cardiovascular diabetology · 2018Review
- Impact of diabetes and early revascularization on the need for late and repeat procedures.Cardiovascular diabetology · 2018Article
- Insulin resistance, blood glucose and inflammatory cytokine levels are risk factors for cardiovascular events in diabetic patients complicated with coronary heart disease.Experimental and therapeutic medicine · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus (DM) is associated with an excess in cardiovascular morbidity and mortality, and is characterized by increased rates of coronary artery disease. Furthermore, once atherosclerosis is established, this is associated with an increased extent, complexity and a more rapid progression than seen in non-DM patients. Ischemia is the single most important predictor of future hard cardiac events and ischemia correction remains the cornerstone of current revascularization strategies. However recent data suggests that, in DM patients, coronary atherosclerosis despite the absence of ischemia, detected by either invasive or non-invasive methods, may not be associated with the same low risk of future cardiac events as seen in non-DM patients. This review seeks to examine the current evidence supporting an ischemia driven revascularization strategy, and to challenge the notion that ischemia is the only clinically relevant factor in the prediction of cardiovascular outcomes in all-comer DM patients. Specifically, we examine whether in DM patients certain characteristics beyond ischemia, such as microvascular disease, coronary atherosclerosis burden, progression and plaque composition, may need to be considered for a more refined risk stratification in these high-risk patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.