ArticleBMC genomics2017
Global analysis of protein lysine succinylation profiles in common wheat.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 73 citations in OpenAlex.
- Infection mechanisms ofiMeta · 2026Article
- The crotonylated and succinylated proteins of jujube involved in phytoplasma-stress responses.BMC biology · 2024Article
- Proteomic Analysis of Lysine Acetylation and Succinylation to Investigate the Pathogenicity of VirulentGenes · 2024Article
- KAT2A changes the function of endometrial stromal cells via regulating the succinylation of ENO1.Open life sciences · 2024Article
- Global Analysis of Lysine Lactylation of Germinated Seeds in Wheat.International journal of molecular sciences · 2023Article
- Comprehensive analysis of the lysine succinylome in fish oil-treated prostate cancer cells.Life science alliance · 2023Article
- Lysine 2-Hydroxyisobutyrylation- and Succinylation-Based Pathways Act Inside Chloroplasts to Modulate Plant Photosynthesis and Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities.Genes & diseases · 2023Review
- Global crotonylatome and GWAS revealed aScience advances · 2023Article
- Proteome-wide analyses reveal diverse functions of protein acetylation and succinylation modifications in fast growing stolons of bermudagrass (Cynodon dactylon L.).BMC plant biology · 2022Article
- Large-scale analysis of protein crotonylation reveals its diverse functions in Pinellia ternata.BMC plant biology · 2022Article
- Global Profiling of 2-hydroxyisobutyrylome in Common Wheat.Genomics, proteomics & bioinformatics · 2022Article
- Article
- The analysis of lysine succinylation modification reveals the mechanism of oxybenzone damaging of pakchoi (Frontiers in plant science · 2022Article
- Proteome-wide analysis of lysine β-hydroxybutyrylation in the myocardium of diabetic rat model with cardiomyopathy.Frontiers in cardiovascular medicine · 2022Article
- Comprehensive analysis of the lysine acetylome and succinylome in the hippocampus of gut microbiota-dysbiosis mice.Journal of advanced research · 2021Article
- First comprehensive analysis of lysine succinylation in paper mulberry (Broussonetia papyrifera).BMC genomics · 2021Article
- Global analysis of lysine 2-hydroxyisobutyrylation in wheat root.Scientific reports · 2021Article
- Systematic analysis of lysine 2-hydroxyisobutyrylation posttranslational modification in wheat leaves.PloS one · 2021Article
- Proteome-Wide Analysis of Lysine 2-Hydroxyisobutyrylated Proteins inFrontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProtein lysine succinylation is an important post-translational modification and plays a critical regulatory role in almost every aspects of cell metabolism in both eukaryotes and prokaryotes. Common wheat is one of the major global cereal crops. However, to date, little is known about the functions of lysine succinylation in this plant. Here, we performed a global analysis of lysine succinylation in wheat and examined its overlap with lysine acetylation.
resultsIn total, 330 lysine succinylated modification sites were identified in 173 proteins. Bioinformatics analysis showed that the modified proteins are distributed in multiple subcellular compartments and are involved in a wide variety of biological processes such as photosynthesis and the Calvin-Benson cycle, suggesting an important role for lysine succinylation in these processes. Five putative succinylation motifs were identified. A protein interaction network analysis revealed that diverse interactions are modulated by protein succinylation. Moreover, 21 succinyl-lysine sites were found to be acetylated at the same position, and 33 proteins were modified by both acetylation and succinylation, suggesting an extensive overlap between succinylation and acetylation in common wheat. Comparative analysis indicated that lysine succinylation is conserved between common wheat and Brachypodium distachyon.
conclusionsThese results suggest that lysine succinylation is involved in diverse biological processes, especially in photosynthesis and carbon fixation. This systematic analysis represents the first global analysis of lysine succinylation in common wheat and provides an important resource for exploring the physiological role of lysine succinylation in this cereal crop and likely in all plants.
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