Evidence map›Paper›PMID 28427010›Full record

ReviewCurrent opinion in biotechnology2017

Leveraging microbial biosynthetic pathways for the generation of 'drop-in' biofuels.

Amin Zargar, Constance B Bailey, Robert W Haushalter, Christopher B Eiben, Leonard Katz, Jay D Keasling

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Article
  3. Dimer-assisted mechanism of (un)saturated fatty acid decarboxylation for alkene production.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Review
  5. Review
  6. Microbial production of advanced biofuels.Nature reviews. Microbiology · 2021
    Review
  7. Computational and structural biotechnology journal · 2021
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Stepwise metabolic engineering ofBiotechnology for biofuels · 2018
    Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Amin ZargarJoint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, United States; QB3 Institute, University of California-Berkeley, 5885 Hollis Street, 4th Floor, Emeryville, CA 94608, United States.
Constance B BaileyJoint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, United States; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.
Robert W HaushalterJoint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, United States; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.
Christopher B EibenJoint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, United States; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.
Leonard KatzJoint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, United States; QB3 Institute, University of California-Berkeley, 5885 Hollis Street, 4th Floor, Emeryville, CA 94608, United States; Synthetic Biology Engineering Research Center, University of California, Berkeley, CA 94720, United States.
Jay D KeaslingJoint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, United States; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States; QB3 Institute, University of California-Berkeley, 5885 Hollis Street, 4th Floor, Emeryville, CA 94608, United States; Synthetic Biology Engineering Research Center, University of California, Berkeley, CA 94720, United States; Department of Chemical & Biomolecular Engineering, Department of Bioengineering, University of California, Berkeley, CA 94720, United States; Novo Nordisk Foundation Center for Biosustainability, Technical University Denmark, DK2970 Horsholm, Denmark. Electronic address: jdkeasling@lbl.gov.
Lawrence Berkeley National Laboratory · USJoint BioEnergy Institute · USNovo Nordisk Foundation · DK

Funding

MOLECULAR BIOPHYSICS TRAINING GRANTT32GM008295 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HURLEY, JAMES H, WEMMER, DAVID E · 1989 to 2022
$8.1M
NIGMS NIH HHS T32 GM008295
6 · The paper itself

Abstract

Advances in retooling microorganisms have enabled bioproduction of 'drop-in' biofuels, fuels that are compatible with existing spark-ignition, compression-ignition, and gas-turbine engines. As the majority of petroleum consumption in the United States consists of gasoline (47%), diesel fuel and heating oil (21%), and jet fuel (8%), 'drop-in' biofuels that replace these petrochemical sources are particularly attractive. In this review, we discuss the application of aldehyde decarbonylases to produce gasoline substitutes from fatty acid products, a recently crystallized reductase that could hydrogenate jet fuel precursors from terpene synthases, and the exquisite control of polyketide synthases to produce biofuels with desired physical properties (e.g., lower freezing points). With our increased understanding of biosynthetic logic of metabolic pathways, we discuss the unique advantages of fatty acid, terpene, and polyketide synthases for the production of bio-based gasoline, diesel and jet fuel.

Indexed as

BiofuelsBiosynthetic PathwaysBacteriaGasolineHydrocarbonsPetroleumPolyketide SynthasesTerpenesBiofuelsGasolineHydrocarbonsJP5 jet fuelPetroleumPolyketide SynthasesTerpenes

Identifiers

PMID28427010
PMCPMC6283405
OpenAlexW2606562059

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.