Evidence map›Paper›PMID 28426952›Full record

ReviewCurrent opinion in chemical biology2017

Plant viruses and bacteriophages for drug delivery in medicine and biotechnology.

Anna E Czapar, Nicole F Steinmetz

Abstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 116 citations in OpenAlex.

  1. Review
  2. Review
  3. Plant-Derived Anti-Cancer Therapeutics and Biopharmaceuticals.Bioengineering (Basel, Switzerland) · 2024
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. The Next Generation of Drug Delivery: Harnessing the Power of Bacteriophages.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  10. Review
  11. Green Biologics: Harnessing the Power of Plants to Produce Pharmaceuticals.International journal of molecular sciences · 2023
    Review
  12. Article
  13. Computational design of non-porous, pH-responsive antibody nanoparticles.bioRxiv : the preprint server for biology · 2023
    Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Anna E CzaparDepartment of Pathology, Case Western Reserve University, Schools of Medicine and Engineering, Cleveland, OH 44106, USA.
Nicole F SteinmetzDepartment of Biomedical Engineering, Case Western Reserve University, Schools of Medicine and Engineering, Cleveland, OH 44106, USA; Department of Radiology, Case Western Reserve University, Schools of Medicine and Engineering, Cleveland, OH 44106, USA; Department of Materials Science and Engineering, Case Western Reserve University, Schools of Medicine and Engineering, Cleveland, OH 44106, USA; Department of Macromolecular Science and Engineering, Case Western Reserve University, Schools of Medicine and Engineering, Cleveland, OH 44106, USA; Division of General Medical Sciences-Oncology, Case Western Reserve University, Schools of Medicine and Engineering, Cleveland, OH 44106, USA. Electronic address: nicole.steinmetz@case.edu.
Case Western Reserve University · USUniversity School · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Clinical and Translational Science Collaborative of ClevelandTL1TR000441 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$2.8M
NCATS NIH HHS TL1 TR000441NIGMS NIH HHS T32 GM007250
6 · The paper itself

Abstract

There are a wide variety of synthetic and naturally occurring nanomaterials under development for nanoscale cargo-delivery applications. Viruses play a special role in these developments, because they can be regarded as naturally occurring nanomaterials evolved to package and deliver cargos. While any nanomaterial has its advantage and disadvantages, viral nanoparticles (VNPs), in particular the ones derived from plant viruses and bacteriophages, are attractive options for cargo-delivery as they are biocompatible, biodegradable, and non-infectious to mammals. Their protein-based structures are often understood at atomic resolution and are amenable to modification with atomic-level precision through chemical and genetic engineering. Here we present a focused review of the emerging technology development of plant viruses and bacteriophages targeting human health and agricultural applications. Key target areas of development are their use in chemotherapy, photodynamic therapy, pesticide-delivery, gene therapy, vaccine carriers, and immunotherapy.

Indexed as

AnimalsBacteriophagesBiotechnologyDrug Delivery SystemsHumansMedicinePlant Viruses

Identifiers

PMID28426952
PMCPMC5488792
OpenAlexW2606565969

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.