ArticlePsycho-oncology2018
Advanced cancer caregiving as a risk for major depressive episodes and generalized anxiety disorder.
Article in Psycho-oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 11 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 11 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- Cancer patient distress and health service use is linked with carer distress: evidence from a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- The benefits of early palliative care on psychological well-being, functional status, and health-related quality of life among cancer patients and their caregivers: a systematic review and meta-analysis.BMC palliative care · 2025Pooled it
- Effects of Telemedicine on Informal Caregivers of Patients in Palliative Care: Systematic Review and Meta-Analysis.JMIR mHealth and uHealth · 2024Pooled it
- Systematic review of caregiver burden, unmet needs and quality-of-life among informal caregivers of patients with pancreatic cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Pooled it
- Depression among caregivers of cancer patients: Updated systematic review and meta-analysis.Psycho-oncology · 2022Pooled it
- Mortality, Morbidity and Health-Related Outcomes in Informal Caregivers Compared to Non-Caregivers: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Resilience in advanced cancer caregiving. A systematic review and meta-synthesis.Palliative medicine · 2022Pooled it
- Systematic Review and Meta-Analysis of Prevalence of Depression Among Caregivers of Cancer Patients.Frontiers in psychiatry · 2022Pooled it
- A systematic review of interventions for family caregivers who care for patients with advanced cancer at home.Patient education and counseling · 2020Pooled it
- Prevalence and determinants of depression in caregivers of cancer patients: A systematic review and meta-analysis.Medicine · 2018Pooled it
- Strategies for Implementing Palliative Care Services for Cancer Patients in Low- and Middle-Income Countries: A Systematic Review.Inquiry : a journal of medical care organization, provision and financingPooled it
- Impact of a psychoeducational intervention to improve caregiver knowledge and attitudes toward palliative cancer care.Patient education and counseling · 2025Trial
- Resilience in middle-aged partners of patients diagnosed with incurable cancer: A thematic analysis.PloS one · 2019Trial
- Factors influencing engagement in an online support group for family caregivers of individuals with advanced cancer.Journal of psychosocial oncologyTrial
- Benefit finding and caregiving burden among primary caregivers of patients with advanced cancer in China: A latent profile analysis.Asia-Pacific journal of oncology nursing · 2026Article
- Poor mental health days and depressive disorders comparing non-caregivers, informal non-cancer caregivers, and informal caregivers of cancer patients: BRFSS 2022-23.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Incongruent symptom perceptions and its associations with negative mood, intimate relationship and quality of life in colorectal cancer dyads: a dyadic analysis.Journal of patient-reported outcomes · 2026Article
- Poor mental health days and depressive disorders by informal cancer patient caregiver status: BRFSS 2022-23.Research square · 2026Article
- Role of Sense of Coherence in Mediating the Relationship Between End-of-Life Caregiving Burden and Bereavement Depressive-Symptom Trajectory.The journal of nursing research : JNR · 2026Article
- Evaluating an AI-Enabled Mobile Mental Health Monitoring Tool Among Family Caregivers of Adults Living With Cancer: Single-Arm Feasibility and Acceptability Trial Protocol.JMIR research protocols · 2026Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveCaregivers of advanced cancer patients provide extensive care associated with high levels of caregiver distress. The degree to which cancer caregiving increases caregivers' risk for a psychiatric disorder is unknown. The current study examines whether advanced cancer caregiving poses distinct risks for initial and recurrent major depressive episodes (MDEs) and generalized anxiety disorder (GAD) relative to the general population.
methodsCaregivers of advanced cancer patients (N = 540) from Coping with Cancer were compared to general population controls (N = 9282) from the National Comorbidity Survey Replication. The general population comparison sample was propensity-weighted to be demographically similar to the caregiver sample.
resultsCaregivers of advanced cancer patients were more likely than individuals in the general population to have an initial MDE (OR = 7.7; 95% CI, 3.5-17.0; P < .001), but no more likely than the general population to have a recurrent MDE (OR = 1.1; 95% CI, 0.6-2.1; P = .662). Caregivers were also more likely than the general population to have GAD (OR = 3.0; 95% CI, 1.9-4.8; P < .001) and comorbid MDE and GAD (OR = 2.5; 95% CI, 1.1-5.9; P = .038).
conclusionsThe increased risk of meeting diagnostic criteria for current MDE and GAD and comorbid MDE and GAD associated with advanced cancer caregiving highlights the degree of emotional burden among cancer caregivers. Clinical services that assess, prevent, and treat depression and anxiety in cancer caregivers are needed to reduce the burden of caregiving and improve the mental health of this growing population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.