Observational studyArthritis care & research2018
Body Mass Index, Weight Loss, and Cause-Specific Mortality in Rheumatoid Arthritis.
Observational study in Arthritis care & research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 52 citations in OpenAlex.
- Muscle morphology changes over 1-year in patients with rheumatoid arthritis: a prospective cohort study using muscle ultrasound.Advances in rheumatology (London, England) · 2026Observational
- Susceptibility to systemic autoimmunity rather than the presence of the HLA-DR4 peptide binding domain alone leads to severe inflammatory arthritis following inhalation of crystalline silica.Particle and fibre toxicology · 2026Article
- Risk and temporal trends of heart failure subtypes in rheumatoid arthritis.Seminars in arthritis and rheumatism · 2025Article
- Longitudinal patterns of obesity index changes and risk of incident rheumatoid arthritis: evidence from a population-based cohort.Arthritis research & therapy · 2025Article
- Inflammatory markers mediate the association between alternative adiposity indices and mortality in patients with rheumatoid arthritis: data from NHANES 1999-2018.Lipids in health and disease · 2025Article
- Observational
- Metabolic Syndrome, Adipokines, and Response to Advanced Therapies in Rheumatoid Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2025Article
- Clinical and metagenomic characteristics of lymphadenopathy related to fever of unknown origin in children.Pediatric research · 2024Article
- Observational
- Effect of Remotely Supervised Weight Loss and Exercise Training Versus Lifestyle Counseling on Cardiovascular Risk and Clinical Outcomes in Older Adults With Rheumatoid Arthritis: A Randomized Controlled Trial.ACR open rheumatology · 2024Article
- Combined repetitive inhalant endotoxin and collagen-induced arthritis drive inflammatory lung disease and arthritis severity in a testosterone-dependent manner.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Cross-sectional associations of low body mass index and being underweight with joint damage in Chinese patients with rheumatoid arthritis.Rheumatology advances in practice · 2024Article
- [Impact of surgical treatment of morbid obesity on joint diseases].Problemy endokrinologii · 2023Review
- A Narrowing Mortality Gap: Temporal Trends of Cause-Specific Mortality in a National Matched Cohort Study in US Veterans With Rheumatoid Arthritis.Arthritis care & research · 2023Article
- Aortic Stenosis Risk in Rheumatoid Arthritis.JAMA internal medicine · 2023Article
- Remotely Supervised Weight Loss and Exercise Training to Improve Rheumatoid Arthritis Cardiovascular Risk: Rationale and Design of the Supervised Weight Loss Plus Exercise Training-Rheumatoid Arthritis Trial.ACR open rheumatology · 2023Review
- Circulating Adipokines and Associations With Incident Cardiovascular Disease in Rheumatoid Arthritis.Arthritis care & research · 2023Article
- Risk of Prostate Cancer in US Veterans With Rheumatoid Arthritis.Arthritis care & research · 2023Article
- The impact of disease severity measures on survival in U.S. veterans with rheumatoid arthritis-associated interstitial lung disease.Rheumatology (Oxford, England) · 2022Article
- Association between being underweight and excess body weight before SARS coronavirus type 2 infection and clinical outcomes of coronavirus disease 2019: Multicenter study.Nutrition (Burbank, Los Angeles County, Calif.) · 2022Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveTo examine associations of body mass index (BMI) and weight loss with cause-specific mortality in rheumatoid arthritis (RA).
methodsA cohort of US veterans with RA was followed until death or through 2013. BMI was categorized as underweight, normal, overweight, and obese. Weight loss was calculated as the 1) annualized rate of change over the preceding 13 months, and 2) cumulative percent. Vital status and cause of death were obtained from the National Death Index. Multivariable competing-risks regression models were utilized to assess the time-varying associations of BMI and weight loss with cause-specific mortality.
resultsAmong 1,600 participants and 5,789 patient-years of followup, 303 deaths occurred (95 cardiovascular, 74 cancer, and 46 respiratory). The highest weight-loss rate and weight-loss percent were associated with a higher risk of cardiovascular mortality (rate: subdistribution hazard ratio [sHR] 2.27 [95% confidence interval (95% CI) 1.61-3.19]; percent: sHR 2.31 [95% CI 1.06-5.01]) and cancer mortality (rate: sHR 2.36 [95% CI 1.11-5.01]; percent: sHR 1.90 [95% CI 1.00-3.62]). Overweight BMI was protective of cardiovascular mortality (sHR 0.59 [95% CI 0.38-0.91]), while underweight BMI was associated with a near 3-fold increased risk of respiratory mortality (sHR 2.93 [95% CI 1.28-6.67]). Incorporation of time-varying BMI and weight loss in the same models did not substantially alter individual associations for cardiovascular and cancer mortality, but an association between weight-loss percentage and respiratory mortality was attenuated after BMI adjustment.
conclusionBoth BMI and weight loss are predictors of cause-specific mortality in RA. Weight loss is a strong predictor of cardiovascular and cancer mortality, while underweight BMI is a stronger predictor of respiratory mortality.
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Registered trials
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