ArticleHuman molecular genetics2016
Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci.
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Article in Human molecular genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
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21citing papers in PubMed, 4 pooled it
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Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers.Nature communications · 2022Pooled it
- Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits.Nature communications · 2022Pooled it
- Minority-centric meta-analyses of blood lipid levels identify novel loci in the Population Architecture using Genomics and Epidemiology (PAGE) study.PLoS genetics · 2020Pooled it
- Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution.Human molecular genetics · 2017Pooled it
- Comparison of the effectiveness of Martin's equation, Friedewald's equation, and a Novel equation in low-density lipoprotein cholesterol estimation.Scientific reports · 2021Trial
- The breadth and impact of the Global Lipids Genetics Consortium.Current opinion in lipidology · 2025Review
- Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review.HGG advances · 2025Review
- Characterizing genetic profiles for high triglyceride levels in U.S. patients of African ancestry.Journal of lipid research · 2024Article
- Leveraging the transcriptome to further our understanding of GWAS findings: eQTLs associated with genes related to LDL and LDL subclasses, in a cohort of African Americans.Frontiers in genetics · 2024Article
- Translating genetic association of lipid levels for biological and clinical application.Cardiovascular drugs and therapy · 2021Review
- Into the Deep: New Data on the Lipid and Fatty Acid Profile of RedfishBiomolecules · 2021Article
- Importance of Genetic Studies of Cardiometabolic Disease in Diverse Populations.Circulation research · 2020Review
- Evaluating the promise of inclusion of African ancestry populations in genomics.NPJ genomic medicine · 2020Review
- Genetic associations between serum low LDL-cholesterol levels and variants in LDLR, APOB, PCSK9 and LDLRAP1 in African populations.PloS one · 2020Article
- The Future of Genomic Studies Must Be Globally Representative: Perspectives from PAGE.Annual review of genomics and human genetics · 2019Review
- Using Genetic Burden Scores for Gene-by-Methylation Interaction Analysis on Metabolic Syndrome in African Americans.Biological research for nursing · 2019Article
- Article
- Insights from population-based analyses of plasma lipids across the allele frequency spectrum.Current opinion in genetics & development · 2018Review
- Sequence Analysis ofFrontiers in genetics · 2018Article
- Genetic architecture of lipid traits in the Hispanic community health study/study of Latinos.Lipids in health and disease · 2017Article
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Authors and funding
57 authors.
Niha ZubairPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Mariaelisa GraffDepartment of Epidemiology.
Jose Luis AmbiteDepartment of Computer Science, University of Southern California, Los Angeles, CA, USA.
William S BushDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
Gleb KichaevBioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA.
Yingchang LuThe Genetics of Obesity and Related Metabolic Traits Program, The Charles Bronfman Institute of Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ani ManichaikulCenter for Public Health Genomics and Biostatistics Section, Department of Public Health Sciences, University of Virginia, Charlottesville, USA.
Wayne H-H SheuDivision of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Devin AbsherHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Themistocles L AssimesDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Suzette J BielinskiDivision of Epidemiology, Mayo Clinic, Rochester MN, USA.
Erwin P BottingerThe Charles Bronfman Institute of Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Petra BuzkovaDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Lee-Ming ChuangDepartment of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Ren-Hua ChungInstitute of Population Health Sciences, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan.
Barbara CochranGenetic Laboratory at the University of Texas Health Science Center, University of Texas, Houston, TX, USA.
Logan DumitrescuCenter for Human Genetics Research, Vanderbilt University, Nashville, TN, USA.
Omri GottesmanThe Charles Bronfman Institute of Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jeffrey W HaesslerWHI Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Christopher HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Gerardo HeissDepartment of Epidemiology.
Chao A HsiungInstitute of Population Health Sciences, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan.
Yi-Jen HungDivision of Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chii-Min HwuSchool of Medicine, National Yang-Ming University, Taipei, Taiwan.
Jyh-Ming J JuangCardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Loic Le MarchandCancer Epidemiology Program, University of Hawai'i Cancer Center, University of Hawai'i at Manoa, Honolulu, Hawai'i. USA.
I-Te LeeDivision of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Wen-Jane LeeDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Li-An LinInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Danyu LinDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Shih-Yi LinDivision of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Rachel H MackeyDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Lisa W MartinCardiology Division, School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.
Bogdan PasaniucBioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA.
Ulrike PetersPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Irene PredazziKnight Cardiovascular Institute, Center for Preventative Cardiology, Oregon Health & Science University, Portland, OR, USA.
Thomas QuertermousDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Alex P ReinerPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Jennifer RobinsonDepartment of Epidemiology, University of Iowa, Iowa City, Iowa, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Kelli K RyckmanDepartment of Epidemiology, University of Iowa, Iowa City, Iowa, USA.
Pamela J SchreinerDivision of Epidemiology & Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
Eli StahlDivision of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ran TaoDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Michael Y TsaiLaboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Lindsay L WaiteHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Tzung-Dau WangCardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Steven BuyskeDepartment of Statistics & Biostatistics, Rutgers University, Piscataway, NJ, USA.
Yii-Der Ida ChenInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Iona ChengCancer Prevention Institute of California, Fremont, CA, USA.
Dana C CrawfordDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
Ruth J F LoosThe Genetics of Obesity and Related Metabolic Traits Program, The Charles Bronfman Institute of Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stephen S RichCenter for Public Health Genomics and Biostatistics Section, Department of Public Health Sciences, University of Virginia, Charlottesville, USA.
Myriam FornageInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Kari E NorthDepartment of Epidemiology.
Charles KooperbergPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Cara L CartyCenter for Translational Science, George Washington University, Children's National Medical Center, Washington, DC, USA.
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MCardiovascular Epidemiology Training GrantT32HL007055 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wayne D. Rosamond · 1986 to 2026
$10.0MEpidemiology of putative genuine genetic variant: The Women's Health IntiativeU01HG004790 · NHGRI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L · 2008 to 2012
$9.9MGenetic Epidemiology of Causal Variants Across the Life CourseU01HG004803 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NORTH, KARI E. · 2008 to 2012
$9.0MEpidemiologic Architecture for Genes Linked to Environment (EAGLE)U01HG004798 · NHGRI · VANDERBILT UNIVERSITY · PI CRAWFORD, DANA C · 2008 to 2013
$8.8MEpidemiology of Putative Causal Variants in the Multiethnic CohortU01HG004802 · NHGRI · UNIVERSITY OF HAWAII AT MANOA · PI LE MARCHAND, LOIC · 2008 to 2012
$8.4MNHGRI EpiGenVar Coordinating CenterU01HG004801 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI MATISE, TARA C. · 2008 to 2012
$4.4MNHGRI PAGE Coordinating CenterU01HG007419 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI BUYSKE, STEVEN G, MATISE, TARA C. · 2013 to 2017
$3.7MDiverse ancestry biobank to map biomedical traits and elucidate health disparitieU01HG007417 · NHGRI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LOOS, RUTH JF · 2013 to 2017
$3.5MExonic variants and their relation to complex traits in minorities of the WHIU01HG007376 · NHGRI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L · 2013 to 2017
$3.2MNHGRI NIH HHS U01 HG004790NHGRI NIH HHS U01 HG004798NHGRI NIH HHS U01 HG004801NHGRI NIH HHS U01 HG004802NHGRI NIH HHS U01 HG004803NHLBI NIH HHS R01 HL163262
Abstract
Genome-wide association studies have identified over 150 loci associated with lipid traits, however, no large-scale studies exist for Hispanics and other minority populations. Additionally, the genetic architecture of lipid-influencing loci remains largely unknown. We performed one of the most racially/ethnically diverse fine-mapping genetic studies of HDL-C, LDL-C, and triglycerides to-date using SNPs on the MetaboChip array on 54,119 individuals: 21,304 African Americans, 19,829 Hispanic Americans, 12,456 Asians, and 530 American Indians. The majority of signals found in these groups generalize to European Americans. While we uncovered signals unique to racial/ethnic populations, we also observed systematically consistent lipid associations across these groups. In African Americans, we identified three novel signals associated with HDL-C (LPL, APOA5, LCAT) and two associated with LDL-C (ABCG8, DHODH). In addition, using this population, we refined the location for 16 out of the 58 known MetaboChip lipid loci. These results can guide tailored screening efforts, reveal population-specific responses to lipid-lowering medications, and aid in the development of new targeted drug therapies.
Indexed as
Genome-Wide Association StudyApolipoprotein A-VAsian PeopleATP Binding Cassette Transporter, Subfamily G, Member 8Black or African AmericanCholesterol, HDLCholesterol, LDLFemaleHispanic or LatinoHumansIndians, North AmericanLipidsLipoprotein LipaseMaleTriglyceridesABCG8 protein, humanAPOA5 protein, humanApolipoprotein A-VATP Binding Cassette Transporter, Subfamily G, Member 8Cholesterol, HDLCholesterol, LDLLipidsLipoprotein LipaseLPL protein, humanTriglycerides
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