Trial reportEuropean heart journal2017
Risk of stroke in chronic heart failure patients with preserved ejection fraction, but without atrial fibrillation: analysis of the CHARM-Preserved and I-Preserve trials.
Trial report in European heart journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04696120 (Effects of APIXaban on BRAIN Protection in Patients With Sinus Rhythm and Heart Failure), which is not on this map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of APIXaban on BRAIN Protection in Patients With Sinus Rhythm and Heart Failure: APIXBRAIN-HF Trial
Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- New-onset atrial fibrillation in patients with worsening heart failure and coronary artery disease: an analysis from the COMMANDER-HF trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Trial
- Arterial Stiffness and Indices of Left Ventricular Diastolic Dysfunction in Patients with Embolic Stroke of Undetermined Etiology.Disease markers · 2019Trial
- Acute Decompensated Heart Failure Complicated by Ischemic Stroke and Its Association With Hemoglobin Levels.Circulation reports · 2026Article
- Long-term outcome of patients with atrial fibrillation and heart failure with preserved ejection fraction after combined radiofrequency catheter ablation and left atrial appendage closure.Frontiers in cardiovascular medicine · 2026Article
- Heart Failure and Stroke: A Narrative Review.Journal of clinical medicine · 2025Review
- The left atrium in heart failure with preserved ejection fraction: What we know and what we do not know.Heart rhythm O2 · 2025Review
- Stroke incidence in heart failure and atrial fibrillation: a population-based retrospective cohort study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025Article
- Phenotypes of atrial fibrillation in a Taiwanese longitudinal cohort: Insights from an Asian perspective.Heart rhythm O2 · 2025Article
- Prognoses and risk stratification of thrombus-associated events in heart failure patients without atrial fibrillation.ESC heart failure · 2024Article
- Equol Nonproducing Status as an Independent Risk Factor for Acute Cardioembolic Stroke and Poor Functional Outcome.Nutrients · 2024Article
- Long-term outcomes in heart failure with preserved ejection fraction: Predictors of cardiac and non-cardiac mortality.ESC heart failure · 2023Article
- Usefulness of B-Type Natriuretic Peptide for Predicting the Risk of Stroke in Patients With Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2022Article
- Cost-effectiveness of adding empagliflozin to the standard therapy for Heart Failure with Preserved Ejection Fraction from the perspective of healthcare systems in China.Frontiers in cardiovascular medicine · 2022Article
- Oral Anticoagulation and Adverse Outcomes after Ischemic Stroke in Heart Failure Patients without Atrial Fibrillation.Journal of cardiac failure · 2021Article
- CBMC medicine · 2021Article
- Risk of stroke in patients with heart failure and sinus rhythm: data from the Swedish Heart Failure Registry.ESC heart failure · 2021Article
- Left Atrial Dilatation and Reduced Left Ventricular Ejection Fraction Are Associated With Cardioembolic Stroke.Frontiers in neurology · 2021Article
- The accuracy of compressed sensing cardiovascular magnetic resonance imaging in heart failure classifications.The international journal of cardiovascular imaging · 2020Article
- Ischemic stroke risk during post-discharge phases of heart failure: association of left ventricular concentric geometry.Heart and vessels · 2020Article
- Long-Term Risk of Stroke and Poststroke Outcomes in Patients with Heart Failure: Two Nationwide Studies.Clinical epidemiology · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 8 institutions in 5 countries.
Funding
Abstract
aimsThe incidence and predictors of stroke in patients with heart failure and preserved ejection fraction (HF-PEF), but without atrial fibrillation (AF), are unknown. We described the incidence of stroke in HF-PEF patients with and without AF and predictors of stroke in those without AF. METHODS AND
resultsWe pooled data from the CHARM-Preserved and I-Preserve trials. Using Cox regression, we derived a model for stroke in patients without AF in this cohort and compared its performance with a published model in heart failure patients with reduced ejection fraction (HF-REF)-predictive variables: age, body mass index, New York Heart Association class, history of stroke, and insulin-treated diabetes. The two stroke models were compared and Kaplan-Meier curves for stroke estimated. The risk model was validated in a third HF-PEF trial. Of the 6701 patients, 4676 did not have AF. Stroke occurred in 124 (6.1%) with AF and in 171 (3.7%) without AF (rates 1.80 and 1.00 per 100 patient-years, respectively). There was no difference in performance of the stroke model derived in the HF-PEF cohort and the published HF-REF model (c-index 0.71, 95% confidence interval 0.57-0.84 vs. 0.73, 0.59-0.85, respectively) as the predictive variables overlapped. The model performed well in the validation cohort (0.86, 0.62-0.99). The rate of stroke in patients in the upper third of risk approximated to that in patients with AF (1.60 and 1.80 per 100 patient-years, respectively).
conclusionsA small number of clinical variables identify a subset of patients with HF-PEF, but without AF, at elevated risk of stroke.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.