ArticlePhysics in medicine and biology2017
Supersonic transient magnetic resonance elastography for quantitative assessment of tissue elasticity.
Article in Physics in medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Accuracy of real-time shear wave elastography in staging hepatic fibrosis: a meta-analysis.BMC medical imaging · 2020Pooled it
- A Dual-Transducer Approach for High-Resolution and High-Precision Shear Wave Elasticity Imaging.Sensors (Basel, Switzerland) · 2025Article
- Magnetic Resonance Acoustic Radiation Force Imaging (MR-ARFI) for the monitoring of High Intensity Focused Ultrasound (HIFU) ablation in anisotropic tissue.Magma (New York, N.Y.) · 2023Article
- A Scholte wave approach for ultrasonic surface acoustic wave elastography.Medical physics · 2023Article
- A Review of Imaging Methods to Assess Ultrasound-Mediated Ablation.BME frontiers · 2022Article
- Magnetic resonance shear wave elastography using transient acoustic radiation force excitations and sinusoidal displacement encoding.Physics in medicine and biology · 2021Article
- Considerations for ultrasound exposure during transcranial MR acoustic radiation force imaging.Scientific reports · 2019Article
- Acoustic radiation force imaging using a single-shot spiral readout.Physics in medicine and biology · 2019Article
- Efficient shear wave elastography using transient acoustic radiation force excitations and MR displacement encoding.Magnetic resonance in medicine · 2019Article
- Production of acoustic radiation force using ultrasound: methods and applications.Expert review of medical devices · 2018Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Non-invasive, quantitative methods to assess the properties of biological tissues are needed for many therapeutic and tissue engineering applications. Magnetic resonance elastography (MRE) has historically relied on external vibration to generate periodic shear waves. In order to focally assess a biomaterial or to monitor the response to ablative therapy, the interrogation of a specific region of interest by a focused beam is desirable and transient MRE (t-MRE) techniques have previously been developed to accomplish this goal. Also, strategies employing a series of discrete ultrasound pulses directed to increasing depths along a single line-of-sight have been designed to generate a quasi-planar shear wave. Such 'supersonic' excitations have been applied for ultrasound elasticity measurements. The resulting shear wave is higher in amplitude than that generated from a single excitation and the properties of the media are simply visualized and quantified due to the quasi-planar wave geometry and the opportunity to generate the wave at the site of interest. Here for the first time, we extend the application of supersonic methods by developing a protocol for supersonic transient magnetic resonance elastography (sst-MRE) using an MR-guided focused ultrasound system capable of therapeutic ablation. We apply the new protocol to quantify tissue elasticity in vitro using biologically-relevant inclusions and tissue-mimicking phantoms, compare the results with elasticity maps acquired with ultrasound shear wave elasticity imaging (US-SWEI), and validate both methods with mechanical testing. We found that a modified time-of-flight (TOF) method efficiently quantified shear modulus from sst-MRE data, and both the TOF and local inversion methods result in similar maps based on US-SWEI. With a three-pulse excitation, the proposed sst-MRE protocol was capable of visualizing quasi-planar shear waves propagating away from the excitation location and detecting differences in shear modulus of 1 kPa. The techniques demonstrated here have potential application in real-time in vivo lesion detection and monitoring, with particular significance for image-guided interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.