Evidence map›Paper›PMID 28426264›Full record

ArticleThe American journal of drug and alcohol abuse2017

Differences between treatment-seeking and non-treatment-seeking participants in medication studies for alcoholism: do they matter?

Lara A Ray, Spencer Bujarski, Megan M Yardley, Daniel J O Roche, Emily E Hartwell

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of drug and alcohol abuse, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  17. Alcohol use disorder severity moderates clinical response to varenicline.Alcoholism, clinical and experimental research · 2021
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Lara A Raya Department of Psychology , University of California , Los Angeles , CA , USA.
Spencer Bujarskia Department of Psychology , University of California , Los Angeles , CA , USA.
Megan M Yardleya Department of Psychology , University of California , Los Angeles , CA , USA.
Daniel J O Rochea Department of Psychology , University of California , Los Angeles , CA , USA.
Emily E Hartwella Department of Psychology , University of California , Los Angeles , CA , USA.

Funding

Optimizing Naltrexone for Individuals of East Asian DescentR01AA021744 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAY, LARA A. · 2013 to 2015
$1.3M
Modeling alcohol reward and reinforcement in the human laboratoryR21AA022752 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAY, LARA A. · 2014 to 2015
$399k
NIAAA NIH HHS R01 AA021744NIAAA NIH HHS R21 AA022752
6 · The paper itself

Abstract

backgroundMedication development for alcoholism typically includes experimental pharmacology studies with non-treatment-seeking individuals with alcohol use disorder (AUD) paving the way for randomized controlled trials in treatment-seekers with AUD.

objectivesThe goal of this study is to provide a direct comparison between AUD treatment-seeking research participants and non-treatment-seeking participants on demographic and clinical variables and to test whether variables that differentiate the two groups are associated with clinical outcomes.

methodNon-treatment-seeking AUD participants (n = 213; 76.3% male) who completed behavioral pharmacology studies were compared to treatment-seekers who completed the COMBINE Study (n = 1383; 69.1% male) on demographic and clinical variables. Analyses examined whether the variables that differentiated the two groups predicted treatment outcomes in the COMBINE Study.

resultsAnalyses revealed that treatment-seeking participants were older, had more years of education, higher Alcohol Dependence Scale scores, higher Drinker Inventory of Consequences scores, higher Obsessive Compulsive Drinking Scale scores, a greater number of DSM-IV symptoms of AUD, longer duration of AUD, and consumed more standard drinks and more drinks per drinking day (i.e., in the past 30 days) compared to non-treatment-seeking participants. Nearly all characteristics that differed between the groups predicted at least one of the primary clinical outcomes of the COMBINE Study.

conclusionsThis study highlights a host of clinical and demographic factors that differ between non-treatment-seeking and treatment-seeking research participants and the clinical significance of these variables. Differences between samples should be considered and addressed in order to promote greater consilience across stages of medication development.

Indexed as

AdultAgedAge FactorsAlcoholismEducational StatusFemaleHumansMaleMiddle AgedPatient Acceptance of Health CareRandomized Controlled Trials as TopicResearch SubjectsTreatment OutcomeYoung Adultalcoholismalcohol use disorderbehavioral pharmacologyclinical trialsTreatment-seeking

Identifiers

PMID28426264
PMCPMC6159933

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.