ArticleAllergy2017
Sputum basophils are increased in eosinophilic asthma compared with non-eosinophilic asthma phenotypes.
Article in Allergy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Diagnostic Use of CCR3, CD63, CD203c and FcεRIα on Blood Leukocytes of Allergic Asthma and Combined Allergic Rhinitis and Asthma Syndrome.Journal of cellular and molecular medicine · 2025Article
- Identification of Novel Biomarkers Associated with Corticosteroid Resistance in Asthma by Bioinformatics Analysis and Experimental Validation.Journal of inflammation research · 2025Article
- Interleukin-33-activated basophils promote asthma by regulating Th2 cell entry into lung tissue.The Journal of experimental medicine · 2024Article
- Multifaceted roles of mitochondria in asthma.Cell biology and toxicology · 2024Review
- Bronchial Asthma and COVID-19: Etiology, Pathological Triggers, and Therapeutic Considerations.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Review
- Effects of increasing sensitizing doses of ovalbumin on airway hyperresponsiveness in asthmatic mice.Immunity, inflammation and disease · 2024Article
- The Functional Role of Group 2 Innate Lymphoid Cells in Asthma.Biomolecules · 2023Review
- Utility of biomarkers in the diagnosis and monitoring of asthmatic children.The World Allergy Organization journal · 2023Review
- Involvement of Transforming Growth Factor-β-Associated Kinase 1 in Fixed Airway Obstruction in Asthmatic Patients with Longer Disease Duration Independent on Airway Eosinophilia.Journal of asthma and allergy · 2023Article
- CD25 as a unique marker on human basophils in stable-mildly symptomatic allergic asthma.Frontiers in immunology · 2022Article
- Role of Basophils in a Broad Spectrum of Disorders.Frontiers in immunology · 2022Review
- Increased expressions of CD123, CD63, CD203c, and Fc epsilon receptor I on blood leukocytes of allergic asthma.Frontiers in molecular biosciences · 2022Article
- Basophils from allergy to cancer.Frontiers in immunology · 2022Review
- Clinical Differences between Early- and Late-Onset Asthma: A Population-Based Cross-Sectional Study.Canadian respiratory journal · 2021Article
- Granulocyte-targeted therapies for airway diseases.Pharmacological research · 2020Review
- Detection of Basophils and Other Granulocytes in Induced Sputum by Flow Cytometry.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care.Allergy · 2019Review
- Phenotype-Specific Therapeutic Effect ofInternational journal of molecular sciences · 2019Article
- Important and specific role for basophils in acute allergic reactions.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Review
- Highlights and recent developments in airway diseases in EAACI journals (2017).Clinical and translational allergy · 2018Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sputum basophil numbers are increased in allergic asthmatics, but it is unclear what role airway basophils play in "TH2-low" asthma phenotypes. Using flow cytometry, we found that basophils were significantly increased in all asthmatics (n=26) compared with healthy controls (n=8) (P=0.007) with highest levels observed in eosinophilic asthma (EA); median 0.22%, IQR 0.11%-0.47%; n=14) compared with non-EA (NEA) (0.06%, 0.00%-0.20%; n=12; P<0.05). In asthmatics, basophils were positively correlated with sputum eosinophils (r=0.54; P<0.005) and inversely with sputum neutrophils (r=-0.46: P<0.05), but not with FEV
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.