ArticleJournal of perinatology : official journal of the California Perinatal Association2017
Validation of mid-infrared spectroscopy for macronutrient analysis of human milk.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- The Nutritional Composition and Energy Content of Donor Human Milk: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Adjusted versus Targeted Fortification in Extremely Low Birth Weight Preterm Infants: Fortin Study-A Randomized Clinical Trial.Nutrients · 2024Trial
- Human milk macronutrient composition and intake in relation to preterm infant growth: a cohort study.Clinical and experimental pediatrics · 2026Article
- Development of home-based methods to defat human milk for infants with chylothorax: An experimental study.JPEN. Journal of parenteral and enteral nutrition · 2025Article
- The Refractive Index of Human Milk Serum: Natural Variations and Dependency on Macronutrient Concentrations.Foods (Basel, Switzerland) · 2024Article
- Comparative analysis of different methods for protein quantification in donated human milk.Frontiers in pediatrics · 2024Article
- Human Milk Calorie Guide: A Novel Color-Based Tool to Estimate the Calorie Content of Human Milk for Preterm Infants.Nutrients · 2023Article
- Improved methods for mare milk analysis: Extraction and quantification of mare milk carbohydrates and assessment of FTIR-based macronutrient quantification.Frontiers in nutrition · 2023Article
- Determinants of fatty acid content and composition of human milk fed to infants born weighing <1250 g.The American journal of clinical nutrition · 2021Article
- Human breast milk-based nutritherapy: A blueprint for pediatric healthcare.Journal of food and drug analysis · 2021Review
- Targeted Breast Milk Fortification for Very Low Birth Weight (VLBW) Infants: Nutritional Intake, Growth Outcome and Body Composition.Nutrients · 2020Article
- Accuracy and Reliability of Infrared Analyzers for Measuring Human Milk Macronutrients in a Milk Bank Setting.Current developments in nutrition · 2019Article
- Transmission infrared spectroscopy for rapid quantification of fat, protein, and lactose concentrations in human milk.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHuman milk has considerable variation in its composition. Hence, the nutrient profile is only an estimate and can result in under- or over-estimation of the intake of preterm infants. Mid-infrared (MIR) spectroscopy is an evolving technique for analyzing human milk but needs validation before use in clinical practice. STUDY
designHuman milk samples from 35 mothers delivering at 35 weeks to term gestation were analyzed for macronutrients by MIR spectroscopy and by standard laboratory methods using Kjeldahl assay for protein, Mojonnier assay for fat and high-pressure liquid chromatography assay for lactose.
resultsMIR analysis of the macronutrients in human milk correlated well with standard laboratory tests with intraclass correlation coefficients of 0.997 for fat, 0.839 for protein and 0.776 for lactose. Agreement between the two methods was excellent for fat, and moderate for protein and lactose (P<0.001).
conclusionsThis methodological paper provides evidence that MIR spectroscopy can be used to analyze macronutrient composition of human milk. Agreement between the methodologies varies by macronutrient.
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