Evidence map›Paper›PMID 28425730›Full record

ArticleNeuropsychology2017

The relation of anxiety and cognition in Parkinson's disease.

Gretchen O Reynolds, Kristine K Hanna, Sandy Neargarder, Alice Cronin-Golomb

Abstract read
In one paragraph

Article in Neuropsychology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gretchen O ReynoldsDepartment of Psychological and Brain Sciences, Boston University.
Kristine K HannaDepartment of Psychological and Brain Sciences, Boston University.
Sandy NeargarderDepartment of Psychological and Brain Sciences, Boston University.
Alice Cronin-GolombDepartment of Psychological and Brain Sciences, Boston University.

Funding

Effects of Parkinson's Disease on Perception, Cognition, and GaitR01NS067128 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CRONIN-GOLOMB, ALICE · 2009 to 2013
$3.2M
MULTIDISCIPLINARY TRAINING PROGRAM IN AGING RESEARCHT32AG000220 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MARKSON, ELIZABETH WARREN · 1993 to 2003
$624k
Optic Flow and Spatial Navigation in Parkinson's DiseaseR21NS043730 · NINDS · BOSTON UNIVERSITY · PI CRONIN-GOLOMB, ALICE M. · 2003 to 2004
$448k
A Cognitive-Behavioral Intervention for Anxiety in Parkinson's DiseaseF31MH102961 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI REYNOLDS, GRETCHEN OLSON · 2013 to 2015
$99k
AARP FoundationBoston University; Department of Psychological and Brain ScienNational Institute of Mental HealthNational Institute of Neurological Disorders and StrokeNational Institute on AgingNIA NIH HHS T32 AG000220NIMH NIH HHS F31 MH102961NINDS NIH HHS R01 NS067128NINDS NIH HHS R21 NS043730
6 · The paper itself

Abstract

objectiveParkinson's disease (PD) has long been conceptualized as a motor disorder, but nonmotor symptoms also manifest in the disease and significantly reduce quality of life. Anxiety and cognitive dysfunction are prevalent nonmotor symptoms, even in early disease stages, but the relation between these symptoms remains poorly understood. We examined self-reported anxiety and neurocognitive function, indexed by measures of executive function (set-shifting and phonemic fluency), categorical fluency, and attention/working memory. We hypothesized that anxiety would correlate with cognitive performance.

methodThe Beck Anxiety Inventory and cognitive tests (Trail Making, Verbal Fluency, Digit Span) were administered to 77 nondemented adults with mild to moderate idiopathic PD (39 men, 38 women; Mage = 62.9 years).

resultsHigher anxiety was associated with more advanced disease stage and severity and with poorer set-shifting when using a derived metric to account for motoric slowing. Depression correlated with greater anxiety and disease severity, but not with cognitive performance.

conclusionsOur findings support the association of anxiety with a specific domain of executive function, set-shifting, in nondemented individuals with mild to moderate PD, raising the possibility that treatment of anxiety may alleviate aspects of executive dysfunction in this population. (PsycINFO Database Record

Indexed as

AgedAnxietyCognitive DysfunctionExecutive FunctionFemaleHumansMaleMiddle AgedParkinson Disease

Identifiers

PMID28425730
PMCPMC5578881

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.