ArticleNature communications2017
Chytrid fungus infection in zebrafish demonstrates that the pathogen can parasitize non-amphibian vertebrate hosts.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Primary tuberculous mycobacterial granulomas provide a niche for superinfecting Mycobacterium abscessus.Nature communications · 2025Article
- An Image Processing Tool for Automated Quantification of Bacterial Burdens in Zebrafish Larvae.Zebrafish · 2025Article
- Double-edged effects of aquatic environmental biofilms onISME communications · 2025Article
- An Image Processing Tool for Automated Quantification of Bacterial Burdens in Zebrafish Larvae.bioRxiv : the preprint server for biology · 2024Article
- Ecological Civilisation and Amphibian Sustainability through Reproduction Biotechnologies, Biobanking, and Conservation Breeding Programs (RBCs).Animals : an open access journal from MDPI · 2024Review
- Stable in vitro fluorescence for enhanced live imaging of infection models for Batrachochytrium dendrobatidis.PloS one · 2024Article
- Drosophila melanogaster as a model arthropod carrier for the amphibian chytrid fungus Batrachochytrium dendrobatidis.PloS one · 2024Article
- AmphibianVirulence · 2023Article
- Alternative Non-Mammalian Animal and Cellular Methods for the Study of Host-Fungal Interactions.Journal of fungi (Basel, Switzerland) · 2023Review
- Zebrafish-based platform for emerging bio-contaminants and virus inactivation research.The Science of the total environment · 2023Review
- Identification of a novel secreted metabolite cyclo(phenylalanyl-prolyl) from Batrachochytrium dendrobatidis and its effect on Galleria mellonella.BMC microbiology · 2022Article
- Fungi as mediators linking organisms and ecosystems.FEMS microbiology reviews · 2022Review
- Direct and Latent Effects of Pathogen Exposure Across Native and Invasive Amphibian Life Stages.Frontiers in veterinary science · 2021Article
- Chytrid fungi and global amphibian declines.Nature reviews. Microbiology · 2020Review
- A historical overview of Batrachochytrium dendrobatidis infection from specimens at the National Zoological Collection Suriname.PloS one · 2020Article
- Characteristics of monolayer formationBiofilm · 2019Article
- Treatment of Chytridiomycosis in Laboratory Axolotls (Comparative medicine · 2019Article
- Risk of survival, establishment and spread ofEFSA journal. European Food Safety Authority · 2018Article
- Tracking the amphibian pathogens Batrachochytrium dendrobatidis and Batrachochytrium salamandrivorans using a highly specific monoclonal antibody and lateral-flow technology.Microbial biotechnology · 2017Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Aquatic chytrid fungi threaten amphibian biodiversity worldwide owing to their ability to rapidly expand their geographical distributions and to infect a wide range of hosts. Combating this risk requires an understanding of chytrid host range to identify potential reservoirs of infection and to safeguard uninfected regions through enhanced biosecurity. Here we extend our knowledge on the host range of the chytrid Batrachochytrium dendrobatidis by demonstrating infection of a non-amphibian vertebrate host, the zebrafish. We observe dose-dependent mortality and show that chytrid can infect and proliferate on zebrafish tissue. We also show that infection phenotypes (fin erosion, cell apoptosis and muscle degeneration) are direct symptoms of infection. Successful infection is dependent on disrupting the zebrafish microbiome, highlighting that, as is widely found in amphibians, commensal bacteria confer protection against this pathogen. Collectively, our findings greatly expand the limited tool kit available to study pathogenesis and host response to chytrid infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.