ArticleScientific reports2017
The effect of hydraulic flowback and produced water on gill morphology, oxidative stress and antioxidant response in rainbow trout (Oncorhynchus mykiss).
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Acute Toxicity of Salinity in Onshore Unconventional Gas Waters to Freshwater Invertebrates in Receiving Environments: A Systematic Review.Environmental toxicology and chemistry · 2022Pooled it
- Challenges and future prospects for developing Ca and Mg water quality guidelines: a meta-analysis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Pooled it
- Chronic toxicity of dissolved barium and sodium chloride to the water flea Ceriodaphnia dubia: implications for unconventional gas flowback-produced waters.Environmental toxicology and chemistry · 2025Article
- Article
- Forensic tracers of exposure to produced water in freshwater mussels: a preliminary assessment of Ba, Sr, and cyclic hydrocarbons.Scientific reports · 2020Article
- The potential for salt toxicity: Can the trans-epithelial potential (TEP) across the gills serve as a metric for major ion toxicity in fish?Aquatic toxicology (Amsterdam, Netherlands) · 2020Article
- Mutagenicity assessment downstream of oil and gas produced water discharges intended for agricultural beneficial reuse.The Science of the total environment · 2020Article
- An integrative method for identification and prioritization of constituents of concern in produced water from onshore oil and gas extraction.Environment international · 2020Article
- Unconventional oil and gas chemicals and wastewater-impacted water samples promote adipogenesis via PPARγ-dependent and independent mechanisms in 3T3-L1 cells.The Science of the total environment · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydraulic fracturing fluid are complex mixtures containing high concentrations of salts (up to 330,000 ppm), organic, and metal contaminants. However, little data exist on the potential mechanisms of toxicity of these flowback and produced wastewaters (FPW) on aquatic biota. Juvenile rainbow trout were exposed to either control, FPW (2.5 or 7.5%), FPW that had been treated with activated charcoal (AC), or a custom salt-matched control (SW; replicating only the salt content of FPW) for 48 hours. Gill histology revealed decreases in interlamellar cell mass (ILCM) and mean lamellar length in all treatments (FPW, AC and SW) compared to control, indicative of hyperosmotic stress. Liver CYP1A1 activity was significantly elevated by 7.5-fold in the FPW 7.5% treatment only, indicative of Phase I metabolism. Superoxide dismutase activity significantly decreased in the gills to all treatments with the lowest activity occurring in the 7.5% FPW group. Catalase activity increased in liver with the highest values noted in fish exposed to 7.5% FPW. No changes were observed with respect to glutathione-S-transferase, while increased lipid peroxidation was only observed in both FPW treatments (2.5, 7.5%). These data suggest a characteristic signature of FPW impact which may help in risk assessment and biomonitoring of FPW spills.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.