Evidence map›Paper›PMID 28425145›Full record

Trial reportJournal of veterinary internal medicine2017

Prevalence of Gastroesophageal Reflux in Cats During Anesthesia and Effect of Omeprazole on Gastric pH.

R S Garcia, P C Belafsky, A Della Maggiore, J M Osborn, B H Pypendop, T Pierce, V J Walker, A Fulton, S L Marks

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of veterinary internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Bacterial Pneumonia in Dogs and Cats: An Update.The Veterinary clinics of North America. Small animal practice · 2020
    Review
  7. Article
  8. Chronic Gingivostomatitis with Esophagitis in Cats.Journal of veterinary internal medicine · 2017
    Article
  9. Spotlight on the perioperative use of maropitant citrate.Veterinary medicine (Auckland, N.Z.) · 2017
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

R S GarciaWilliam R. Pritchard Veterinary Medical Teaching Hospital (VMTH), School of Veterinary Medicine, University of California, Davis, CA.
P C BelafskyDepartment of Otolaryngology, Center for Voice and Swallowing, School of Medicine, University of California, Davis, Sacramento, CA.
A Della MaggioreDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA.
J M OsbornSandhill Scientific, Inc., Highlands Ranch, CO.
B H PypendopDepartment of Surgery and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA.
T PierceDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA.
V J WalkerWilliam R. Pritchard Veterinary Medical Teaching Hospital (VMTH), School of Veterinary Medicine, University of California, Davis, CA.
A FultonWilliam R. Pritchard Veterinary Medical Teaching Hospital (VMTH), School of Veterinary Medicine, University of California, Davis, CA.
S L MarksDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA.ORCID http://orcid.org/0000-0001-7991-702X
University of California, Davis · USVeterinary Medical Teaching Hospital · USAdvanced Emissions Solutions (United States) · USShanghai Tunnel Engineering (China) · CNUniversity of California Davis Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastroesophageal reflux (GER) is poorly characterized in anesthetized cats, but can cause aspiration pneumonia, esophagitis, and esophageal stricture formation.

objectiveTo determine whether pre-anesthetic orally administered omeprazole increases gastric and esophageal pH and increases serum gastrin concentrations in anesthetized cats, and to determine the prevalence of GER using combined multichannel impedance and pH monitoring. ANIMALS: Twenty-seven healthy cats undergoing elective dental procedures.

methodsProspective, double-masked, placebo-controlled, randomized clinical trial. Cats were randomized to receive 2 PO doses of omeprazole (1.45-2.20 mg/kg) or an empty gelatin capsule placebo 18-24 hours and 4 hours before anesthetic induction. Blood for measurement of serum gastrin concentration was collected during anesthetic induction. An esophageal pH/impedance catheter was utilized to continuously measure esophageal pH and detect GER throughout anesthesia.

resultsMean gastric pH in the cats that received omeprazole was 7.2 ± 0.4 (range, 6.6-7.8) and was significantly higher than the pH in cats that received the placebo 2.8 ± 1.0 (range, 1.3-4.1; P < .001). Omeprazole administration was not associated with a significant increase in serum gastrin concentration (P = .616). Nine of 27 cats (33.3%) had ≥1 episode of GER during anesthesia. CONCLUSIONS AND CLINICAL RELEVANCE: Pre-anesthetic administration of 2 PO doses of omeprazole at a dosage of 1.45-2.20 mg/kg in cats was associated with a significant increase in gastric and esophageal pH within 24 hours, but was not associated with a significant increase in serum gastrin concentration. Prevalence of reflux events in cats during anesthesia was similar to that of dogs during anesthesia.

Indexed as

Administration, OralAnesthesiaAnimalsAnti-Ulcer AgentsCat DiseasesCatsEsophagusFemaleGastroesophageal RefluxHydrogen-Ion ConcentrationMaleOmeprazoleProspective StudiesTreatment OutcomeAnti-Ulcer AgentsOmeprazoleEsophagitisFelineGastric pHImpedanceReflux

Identifiers

PMID28425145
PMCPMC5435072
OpenAlexW2607343084

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.