ArticleBrain structure & function2017
Risk and protective factors for structural brain ageing in the eighth decade of life.
Article in Brain structure & function, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Apolipoprotein E Genotype Moderation of the Association Between Physical Activity and Brain Health. A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2021Pooled it
- Characterization of White Matter Hyperintensities in Large-Scale MRI-Studies.Frontiers in neurology · 2019Pooled it
- Effect of Ibuprofen on BrainAGE: A Randomized, Placebo-Controlled, Dose-Response Exploratory Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Trial
- Article
- Association between allostatic load and accelerated white matter brain aging: findings from the UK Biobank.American journal of epidemiology · 2025Article
- Allostatic load, a measure of cumulative physiological stress, impairs brain structure but notFrontiers in aging neuroscience · 2025Article
- Association between allostatic load and accelerated white matter brain aging: findings from the UK Biobank.medRxiv : the preprint server for health sciences · 2024Article
- Comprehensive allostatic load risk index is associated with increased frontal and left parietal white matter hyperintensities in mid-life cognitively healthy adults.Scientific reports · 2024Article
- Cognitive Change Before Old Age (11 to 70) Predicts Cognitive Change During Old Age (70 to 82).Psychological science · 2022Article
- Linking objective measures of physical activity and capability with brain structure in healthy community dwelling older adults.NeuroImage. Clinical · 2021Article
- Discovering correlates of age-related decline in a healthy late-midlife male birth cohort.Aging · 2020Article
- Psychotic-like experiences, polygenic risk scores for schizophrenia, and structural properties of the salience, default mode, and central-executive networks in healthy participants from UK Biobank.Translational psychiatry · 2020Article
- Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: mega-analytic findings from a large multi-site cohort.Psychological medicine · 2020Article
- Cumulative Effects of Prior Concussion and Primary Sport Participation on Brain Morphometry in Collegiate Athletes: A Study From the NCAA-DoD CARE Consortium.Frontiers in neurology · 2020Article
- Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Review
- Discovering markers of healthy aging: a prospective study in a Danish male birth cohort.Aging · 2019Article
- Defining Cognitive Reserve and Implications for Cognitive Aging.Current neurology and neuroscience reports · 2019Review
- Polygenic risk score for schizophrenia and structural brain connectivity in older age: A longitudinal connectome and tractography study.NeuroImage · 2018Article
- Cohort Profile Update: The Lothian Birth Cohorts of 1921 and 1936.International journal of epidemiology · 2018Article
- Allostatic load as a predictor of grey matter volume and white matter integrity in old age: The Whitehall II MRI study.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
Individuals differ markedly in brain structure, and in how this structure degenerates during ageing. In a large sample of human participants (baseline n = 731 at age 73 years; follow-up n = 488 at age 76 years), we estimated the magnitude of mean change and variability in changes in MRI measures of brain macrostructure (grey matter, white matter, and white matter hyperintensity volumes) and microstructure (fractional anisotropy and mean diffusivity from diffusion tensor MRI). All indices showed significant average change with age, with considerable heterogeneity in those changes. We then tested eleven socioeconomic, physical, health, cognitive, allostatic (inflammatory and metabolic), and genetic variables for their value in predicting these differences in changes. Many of these variables were significantly correlated with baseline brain structure, but few could account for significant portions of the heterogeneity in subsequent brain change. Physical fitness was an exception, being correlated both with brain level and changes. The results suggest that only a subset of correlates of brain structure are also predictive of differences in brain ageing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.